Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat

D. Reglodi, Aniko Somogyvari-Vigh, Jerome L. Maderdrut, Sandor Vigh, Akira Arimura

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

This study examined the time course and effects of postischemic spontaneous hyperthermia after transient and permanent focal ischemia. Rats underwent a 90-min, 120-min, or permanent middle cerebral artery occlusion (MCAO). Body temperatures started rising 15-20 min after MCAO and reached 39- 40.5°C during the first hour. Sustained hyperthermia was observed during the rest of the first 24 h. In another experiment, rats were subjected to the same interventions, but a normothermic body temperature was maintained. Spontaneous hyperthermia significantly increased the infarct volumes measured 48 h after MCAO in all groups. Reperfusion 2 h after the onset of ischemia was not beneficial in the hyperthermic animals in contrast to the normothermic group. We also examined the effect of spontaneous hyperthermia on the temporal progression of infarcted and penumbral areas 4, 12, or 48 h after MCAO. During spontaneous hyperthermia, penumbral areas became infarcted areas more rapidly, which was most expressed at 4 h. These findings demonstrate that severe spontaneous hyperthermia can occur in rats after MCAO and that it not only increases the infarct volumes in both transient and permanent ischemia, but also accelerates the incorporation of penumbral areas into necrotic areas, which significantly decreases the window of opportunity for therapeutic interventions. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)399-407
Number of pages9
JournalExperimental Neurology
Volume163
Issue number2
DOIs
Publication statusPublished - Jun 2000

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Middle Cerebral Artery Infarction
Fever
Ischemia
Body Temperature
Reperfusion

Keywords

  • Cerebral ischemia
  • Focal ischemia
  • Hyperthermia
  • Middle cerebral artery occlusion
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat. / Reglodi, D.; Somogyvari-Vigh, Aniko; Maderdrut, Jerome L.; Vigh, Sandor; Arimura, Akira.

In: Experimental Neurology, Vol. 163, No. 2, 06.2000, p. 399-407.

Research output: Contribution to journalArticle

Reglodi, D. ; Somogyvari-Vigh, Aniko ; Maderdrut, Jerome L. ; Vigh, Sandor ; Arimura, Akira. / Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat. In: Experimental Neurology. 2000 ; Vol. 163, No. 2. pp. 399-407.
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