Postirradiation angiosarcoma of the chest wall and breast: Issues of radiogenic origin, diagnosis and treatment in two cases

C. Polgár, Z. Orosz, A. Szerdahelyi, J. Fodor, T. Major, A. Mágori, F. Czeyda-Pommersheim, I. Vámosi Nagy, I. Szakolczai, Z. Fejös, G. Németh

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Abstract

The authors report two cases of postradiation angiosarcoma (AS) among 5,100 breast cancer patients treated in the period 1980-1994 at the National Institute of Oncology, Budapest. Relevant data in the literature is also reviewed to analyze the questions of radiogenic origin, diagnosis and treatment. Secondary AS occurred in these cases in a previously irradiated field after a 6- and 8-year latency period, respectively. Detailed histopathological and immunohistochemical examinations from the biopsy specimens confirmed the diagnosis as AS. The first patient was treated successfully with radical surgery. The second patient, with unresectable AS, died of rapid local progression within 4 months. The incidence of chest wall and breast AS after radiotherapy was found to be 0.46 per 1,000 in our patient population, which means an estimated odds ratio of 2.9 for secondary AS. Patients treated with radiotherapy for primary breast cancer are at higher risk for developing secondary AS compared to the healthy population. An etiological relationship between radiotherapy and subsequent AS of the chest wall and breast is likely, but still controversial. Initial radical surgery is the only effective treatment for achieving long-term survival. These very rare cases deserve special attention due to the atypical clinical appearance, difficulties of differential diagnosis and poor prognosis.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalOncology
Volume60
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Hemangiosarcoma
Thoracic Wall
Breast
Radiotherapy
Therapeutics
Breast Neoplasms
Population
Differential Diagnosis
Odds Ratio
Biopsy
Survival
Incidence

Keywords

  • Angiosarcoma
  • Breast cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Postirradiation angiosarcoma of the chest wall and breast : Issues of radiogenic origin, diagnosis and treatment in two cases. / Polgár, C.; Orosz, Z.; Szerdahelyi, A.; Fodor, J.; Major, T.; Mágori, A.; Czeyda-Pommersheim, F.; Vámosi Nagy, I.; Szakolczai, I.; Fejös, Z.; Németh, G.

In: Oncology, Vol. 60, No. 1, 2001, p. 31-34.

Research output: Contribution to journalArticle

Polgár, C, Orosz, Z, Szerdahelyi, A, Fodor, J, Major, T, Mágori, A, Czeyda-Pommersheim, F, Vámosi Nagy, I, Szakolczai, I, Fejös, Z & Németh, G 2001, 'Postirradiation angiosarcoma of the chest wall and breast: Issues of radiogenic origin, diagnosis and treatment in two cases', Oncology, vol. 60, no. 1, pp. 31-34. https://doi.org/10.1159/000055293
Polgár, C. ; Orosz, Z. ; Szerdahelyi, A. ; Fodor, J. ; Major, T. ; Mágori, A. ; Czeyda-Pommersheim, F. ; Vámosi Nagy, I. ; Szakolczai, I. ; Fejös, Z. ; Németh, G. / Postirradiation angiosarcoma of the chest wall and breast : Issues of radiogenic origin, diagnosis and treatment in two cases. In: Oncology. 2001 ; Vol. 60, No. 1. pp. 31-34.
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