Posztkondicionálás - A távoli szervi dysfunctiók ellenszere?

Translated title of the contribution: [Postconditioning -- effective method against distant organ dysfunction?].

Péter Onody, Olivér Rosero, Tibor Kovács, Dávid Garbaisz, Viktor Hegedüs, G. Lotz, László Harsányi, Attila Szijártó

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The ischemia-reperfusion injury of the small intestine is a condition of high mortality, which occurs following superior mesenteric artery (SMA) embolization or circulatory redistribution. The aim of the study was to evaluate the local and systemic effects of postconditioning in a rat model of small intestine ischemia-reperfusion. Male Wistar rats underwent 60 min ischemia by the clamping of the SMA, followed by 6 hrs of reperfusion. The animals (n = 30) were randomized into three groups: sham-operated, control-, and postconditioned. Postconditioning was performed at the very onset of reperfusion by 6 alternating cycles of 10-10 seconds reperfusion/reocclusion, for a total of 2 min. At the end of the reperfusion blood and tissue (small intestine, lungs, kidney, liver) samples were taken for histological examination. The antioxidant status of small intestine was measured from intestinal homogenates. Histologic results revealed increased damage in control-group lungs, kidney, liver and small intestine in comparison with the postconditioned group. The injury was supported by significantly higher wet/dry weight ratio (p = 0.026), and serum levels of creatinine (p = 0.013), ASAT (p = 0.038), LDH (p = 0.028) and CK (p = 0.038) in the control group. The postconditioned group showed lower serum IL-6 levels (420 pg/ml vs. 188 pg/ml), as well as significantly higher mucosal antioxidant concentration. Postconditioning was able to decrease not only local, but the systemic damage intensity also, after a small intestinal ischemic-reperfusion episode.

Original languageHungarian
Pages (from-to)222-229
Number of pages8
JournalMagyar sebészet
Volume65
Issue number4
Publication statusPublished - Aug 2012

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Reperfusion
Small Intestine
Superior Mesenteric Artery
Ischemia
Antioxidants
Kidney
Lung
Control Groups
Liver
Reperfusion Injury
Serum
Constriction
Wistar Rats
Interleukin-6
Creatinine
Weights and Measures
Mortality
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Onody, P., Rosero, O., Kovács, T., Garbaisz, D., Hegedüs, V., Lotz, G., ... Szijártó, A. (2012). Posztkondicionálás - A távoli szervi dysfunctiók ellenszere? Magyar sebészet, 65(4), 222-229.

Posztkondicionálás - A távoli szervi dysfunctiók ellenszere? / Onody, Péter; Rosero, Olivér; Kovács, Tibor; Garbaisz, Dávid; Hegedüs, Viktor; Lotz, G.; Harsányi, László; Szijártó, Attila.

In: Magyar sebészet, Vol. 65, No. 4, 08.2012, p. 222-229.

Research output: Contribution to journalArticle

Onody, P, Rosero, O, Kovács, T, Garbaisz, D, Hegedüs, V, Lotz, G, Harsányi, L & Szijártó, A 2012, 'Posztkondicionálás - A távoli szervi dysfunctiók ellenszere?', Magyar sebészet, vol. 65, no. 4, pp. 222-229.
Onody P, Rosero O, Kovács T, Garbaisz D, Hegedüs V, Lotz G et al. Posztkondicionálás - A távoli szervi dysfunctiók ellenszere? Magyar sebészet. 2012 Aug;65(4):222-229.
Onody, Péter ; Rosero, Olivér ; Kovács, Tibor ; Garbaisz, Dávid ; Hegedüs, Viktor ; Lotz, G. ; Harsányi, László ; Szijártó, Attila. / Posztkondicionálás - A távoli szervi dysfunctiók ellenszere?. In: Magyar sebészet. 2012 ; Vol. 65, No. 4. pp. 222-229.
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