Alsó végtagi ischaemiás-reperfusiós károsodás hosszú távú tüdoszövodményeinek megelozése posztkondicionálással.

Translated title of the contribution: [Postconditioning can reduce long-term lung injury after lower limb ischemia-reperfusion].

Dávid Garbaisz, Zsolt Turóczi, András Fülöp, Olivér Rosero, Péter Arányi, Péter Ónody, Gábor Lotz, Zoltán Rakonczay, Zsolt Balla, László Harsányi, Attila Szijártó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Operation on the infrarenal aorta could cause ischemic-reperfusion (IR) injury in local tissues and remote organs (e.g. the lung). Our aim was to reduce long-term lung damage, after lower limb IR with postconditioning. Male Wistar rats underwent 180 minutes of bilateral lower limb ischemia. Animals were divided into three groups: Sham-operated, IR, Postconditioned (PostC) and further to two subgroups according to reperfusion time: 24 h and 72 h. Serum free radical and IL-6 levels, histological changes, Wet/Dry (W/D) ratio, tissue myeloperoxidase (MPO) activity and Hsp72 levels were investigated. Postconditioning can reduce histological changes in the lung. Free radical levels are significantly lower in PostC groups than in IR groups (42.9 ± 8.0 vs. 6.4 ± 3.4; 27.3 ± 4.4 vs. 8.3 ± 4.0 RLU%; p < 0.05). IL-6 level (238.4 ± 31.1 vs. 209.1 ± 18.8; 190.0 ± 8.8 vs. 187.0 ± 14.9 pg/ml) and Hsp72 expression did not show any significant difference. Compared to the IR group, lung MPO activity did not change in the PostC groups. W/D ratio in PostC groups is significantly lower at all measured time-points (68% vs. 65%; 72% vs. 68%; p < 0.05). Postconditioning may reduce long-term damages of the lung after lower limb ischemic-reperfusion injury.

Translated title of the contribution[Postconditioning can reduce long-term lung injury after lower limb ischemia-reperfusion].
Original languageHungarian
Pages (from-to)146-154
Number of pages9
JournalUnknown Journal
Volume66
Issue number3
DOIs
Publication statusPublished - Jun 2013

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Garbaisz, D., Turóczi, Z., Fülöp, A., Rosero, O., Arányi, P., Ónody, P., Lotz, G., Rakonczay, Z., Balla, Z., Harsányi, L., & Szijártó, A. (2013). Alsó végtagi ischaemiás-reperfusiós károsodás hosszú távú tüdoszövodményeinek megelozése posztkondicionálással. Unknown Journal, 66(3), 146-154. https://doi.org/10.1556/MaSeb.66.2013.3.3