Post-transplant diabetes mellitus - Risk factors and effects on the function and morphology of the allograft

B. Borda, C. Lengyel, E. Szederkényi, J. Eller, C. S. Keresztes, G. Lazar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The incidence of post-transplant diabetes mellitus and its effects on the kidney allograft function and morphology were assessed. Patients were divided into three groups according to their glucose metabolism. Risk factors for diabetes were first assessed, and then changes in renal function were checked. Morphological changes in the allografts were examined by protocol biopsies. The overall incidence of diabetes was 16%. The development of diabetes was influenced significantly by the body mass index, the body weight and the age of the recipient. The incidence of diabetes was 8.6% in patients on cyclosporine A therapy and 28.8% in those on tacrolimus ( p <0.05). As to the morphology of the kidney, a significantly higher proportion of the biopsies showed severe interstitial fibrosis/tubular atrophy ( p = 0.0004) and subclinical acute rejection ( p = 0.001) in the diabetic group compared to the normal one. This clinical study has revealed that the adverse effect of diabetes on the allograft can be detected with protocol biopsy before the manifestation of a functional deterioration.

Original languageEnglish
Pages (from-to)206-215
Number of pages10
JournalActa Physiologica Hungarica
Volume99
Issue number2
DOIs
Publication statusPublished - Jun 1 2012

Fingerprint

Allografts
Diabetes Mellitus
Transplants
Kidney
Biopsy
Incidence
Tacrolimus
Cyclosporine
Atrophy
Body Mass Index
Fibrosis
Body Weight
Glucose
Therapeutics
Clinical Studies

Keywords

  • Immunosuppressive therapy
  • Post-transplant diabetes mellitus
  • Protocol biopsy

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Post-transplant diabetes mellitus - Risk factors and effects on the function and morphology of the allograft. / Borda, B.; Lengyel, C.; Szederkényi, E.; Eller, J.; Keresztes, C. S.; Lazar, G.

In: Acta Physiologica Hungarica, Vol. 99, No. 2, 01.06.2012, p. 206-215.

Research output: Contribution to journalArticle

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