Post-source decay matrix-assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3-dihydro-1,5-benzothiazepines

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Abstract

The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5- benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these ([M+Ag]+) compounds was observed. It was also found that [M+Ag]+ produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H]+ and [M+Ag]+ precursor ions.

Original languageEnglish
Pages (from-to)1259-1264
Number of pages6
JournalRapid Communications in Mass Spectrometry
Volume18
Issue number12
DOIs
Publication statusPublished - 2004

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Ionization
Desorption
Ions
Lasers
Silver
1,5-benzothiazepine
Cations
Protons
Derivatives

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

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title = "Post-source decay matrix-assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3-dihydro-1,5-benzothiazepines",
abstract = "The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5- benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these ([M+Ag]+) compounds was observed. It was also found that [M+Ag]+ produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H]+ and [M+Ag]+ precursor ions.",
author = "S. K{\'e}ki and Lajos Nagy and G. De{\'a}k and A. L{\'e}vai and M. Zsuga",
year = "2004",
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pages = "1259--1264",
journal = "Rapid Communications in Mass Spectrometry",
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TY - JOUR

T1 - Post-source decay matrix-assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3-dihydro-1,5-benzothiazepines

AU - Kéki, S.

AU - Nagy, Lajos

AU - Deák, G.

AU - Lévai, A.

AU - Zsuga, M.

PY - 2004

Y1 - 2004

N2 - The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5- benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these ([M+Ag]+) compounds was observed. It was also found that [M+Ag]+ produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H]+ and [M+Ag]+ precursor ions.

AB - The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5- benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these ([M+Ag]+) compounds was observed. It was also found that [M+Ag]+ produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H]+ and [M+Ag]+ precursor ions.

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DO - 10.1002/rcm.1476

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