Post-source decay matrix-assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3-dihydro-1,5-benzothiazepines

Research output: Contribution to journalArticle

1 Citation (Scopus)


The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5- benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these ([M+Ag]+) compounds was observed. It was also found that [M+Ag]+ produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H]+ and [M+Ag]+ precursor ions.

Original languageEnglish
Pages (from-to)1259-1264
Number of pages6
JournalRapid Communications in Mass Spectrometry
Issue number12
Publication statusPublished - Jul 12 2004


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Cite this