Possible role of serotonin in the monoamines induced inhibition of the stress mechanism in the rat

I. Vermes, G. Dull, G. Telegdy, K. Lissak

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Intraventricularly administered 5 μg dopamine, 5 μg norepinephrine or 165 μg melatonin inhibited the activation by surgical stress of the pituitary adrenal system, and increased the hypothalamic serotonin content. p Chlorophenylalanine (300 μg/kg b.w.) prevented the inhibition by monoamines of the stress by lowering the serotonin content in the hypothalamus. According to the results, the inhibition of stress by monoamines is mediated via increased hypothalamic serotonin content.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalActa physiologica Academiae Scientiarum Hungaricae
Issue number3
Publication statusPublished - Dec 1 1972


ASJC Scopus subject areas

  • Physiology

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