Possible role of formaldehyde in the apoptotic and mitotic effect of 1-methyl-ascorbigen

B. Szende, E. Tyihák, Gyula Szókán, György Kätay

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

PC-3 human prostate carcinoma cells were treated with 100 ug/ml 1-methyl-ascorbigen (Me-Asc). This treatment resulted in a significant decrease in tumor cell number in parallel with an increase in apoptotic cells. The formaldehyde (HCHO) level in the culture medium was also increased. Dimedone (Di), a known capture molecule forming formaldemethone with HCHO, applied simultaneously with Me-Asc in 10 ug/ml doses diminished the apoptosis-inducing effect of Me-Asc. The possible role of in situ generated HCHO in the induction of apoptosis is discussed.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalPathology and Oncology Research
Volume1
Issue number1
DOIs
Publication statusPublished - Mar 1995

Fingerprint

Formaldehyde
Apoptosis
Culture Media
Prostate
Cell Count
Carcinoma
ascorbigen
Neoplasms
dimedone
formaldemethone

Keywords

  • apoptosis
  • formaldehyde
  • methylascorbigen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Possible role of formaldehyde in the apoptotic and mitotic effect of 1-methyl-ascorbigen. / Szende, B.; Tyihák, E.; Szókán, Gyula; Kätay, György.

In: Pathology and Oncology Research, Vol. 1, No. 1, 03.1995, p. 38-42.

Research output: Contribution to journalArticle

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