Possible role for platelet insulin receptors in modulating platelet function in health and diabetes mellitus

M. Udvardy, E. Posan, J. Hársfalvi, K. Rak

Research output: Contribution to journalArticle

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Abstract

Binding studies have shown that human platelets contain binding sites for insulin with a surface density similar to that described for other cells.1 Evidence for a reduced number and affinity of human platelet membrane insulin binding sites in non-insulin dependent diabetes mellitus (NIDDM) has been provided.2 However, the influence of insulin and insulin receptors on platelet function has not been completely investigated and clarified. Falcon et al3 reported phosphorylation of a subunit of the insulin receptor on platelets in response to insulin, but no alterations were detected in cAMP formation or degradation, inositol phosphate formation or phosphorylation of proteins other than the receptor itself. On the other hand Trovati et al4 found reduced platelet aggregation responses to ADP, PAF, epinephrine, collagen and arachidonate in the presence of 40 μU/ml insulin. Their experience with an euglycemic-hyperinsulinemic clamp provided some further in vivo evidence to support the above mentioned findings. Platelet thromboxane A2 formation was not altered in the presence of the hormone.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalPlatelets
Volume4
Issue number5
DOIs
Publication statusPublished - 1993

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Insulin Receptor
Diabetes Mellitus
Blood Platelets
Insulin
Health
Binding Sites
Phosphorylation
Thromboxane A2
Glucose Clamp Technique
Inositol Phosphates
Platelet Aggregation
Adenosine Diphosphate
Type 2 Diabetes Mellitus
Epinephrine
Collagen
Hormones
Membranes
Proteins

ASJC Scopus subject areas

  • Hematology
  • Cell Biology

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Possible role for platelet insulin receptors in modulating platelet function in health and diabetes mellitus. / Udvardy, M.; Posan, E.; Hársfalvi, J.; Rak, K.

In: Platelets, Vol. 4, No. 5, 1993, p. 287-288.

Research output: Contribution to journalArticle

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