Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring: A population-based case-control study

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BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95% CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Issue number8
Publication statusPublished - Aug 1 2008



  • Acute pelvic inflammatory disease
  • Cardiovascular malformations (atrial septal defects)
  • Congenital abnormalities
  • High fever
  • Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology

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