Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring: A population-based case-control study

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Abstract

BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95% CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume82
Issue number8
DOIs
Publication statusPublished - Aug 2008

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Pelvic Inflammatory Disease
Case-Control Studies
Pregnant Women
Population
Mothers
Cardiovascular Abnormalities
Atrial Heart Septal Defects
Fever

Keywords

  • Acute pelvic inflammatory disease
  • Cardiovascular malformations (atrial septal defects)
  • Congenital abnormalities
  • High fever
  • Pregnancy

ASJC Scopus subject areas

  • Developmental Biology

Cite this

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title = "Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring: A population-based case-control study",
abstract = "BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29{\%}) cases and 128 out of 38,151 (0.34{\%}) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95{\%} CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95{\%} CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation.",
keywords = "Acute pelvic inflammatory disease, Cardiovascular malformations (atrial septal defects), Congenital abnormalities, High fever, Pregnancy",
author = "N{\'a}ndor {\'A}cs and Ferenc B{\'a}nhidy and Puh{\'o}, {Erzs{\'e}bet H.} and Czeizel, {Andrew E.}",
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AU - Ács, Nándor

AU - Bánhidy, Ferenc

AU - Puhó, Erzsébet H.

AU - Czeizel, Andrew E.

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N2 - BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95% CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation.

AB - BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95% CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation.

KW - Acute pelvic inflammatory disease

KW - Cardiovascular malformations (atrial septal defects)

KW - Congenital abnormalities

KW - High fever

KW - Pregnancy

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