A postresuscitatiós ellátás neuroprotekciós lehetoségei 2019-ben

Translated title of the contribution: Possibilities of post-resuscitation neuroprotection in 2019

Research output: Contribution to journalArticle

Abstract

Post-resuscitation brain injury forms the leading cause of death of patients after successful cardiopulmonary resuscitation that explains why post-resuscitation neuroprotection is the most important part of post-resuscitation therapy. The goals of the neuroprotection tools available today are preventing the evolution of primary and formation of secondary brain injury. We are going to summarize the neuroprotective possibilities that we can reach today. We will discuss the role of pharmacologic strategies including sedation, the modalities of upholding brain perfusion, the monitoring of proper hemodynamic variables and the practice of targeted temperature management. It is very important to avoid hypo- A nd hyperoxia, to keep normocapnia, normoglycemia and to control seizures during the management of post-cardiac arrest patients. There is still a lack of evidence to prove which pharmacologic agent may be effective in postresuscitation neuroprotection, however, there are some promising results regarding thiamine. Hemodynamic management guided by higher level hemodynamic monitoring may be beneficial in enhancing brain perfusion but more clinical studies are needed to investigate its usefulness. Targeted temperature management constitutes the main element of post-resuscitation neuroprotection, however, the details of its implementation raise several questions.

Original languageHungarian
Pages (from-to)1832-1839
Number of pages8
JournalOrvosi hetilap
Volume160
Issue number46
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Resuscitation
Hemodynamics
Brain Injuries
Perfusion
Hyperoxia
Temperature
Thiamine
Cardiopulmonary Resuscitation
Brain
Heart Arrest
Cause of Death
Seizures
Neuroprotection
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A postresuscitatiós ellátás neuroprotekciós lehetoségei 2019-ben. / Eniko, Kovács; János, Gál; Béla, Merkely; Endre, Zima.

In: Orvosi hetilap, Vol. 160, No. 46, 01.01.2019, p. 1832-1839.

Research output: Contribution to journalArticle

@article{e25ee7ccdeab42f4a9d7012883a03ff0,
title = "A postresuscitati{\'o}s ell{\'a}t{\'a}s neuroprotekci{\'o}s lehetos{\'e}gei 2019-ben",
abstract = "Post-resuscitation brain injury forms the leading cause of death of patients after successful cardiopulmonary resuscitation that explains why post-resuscitation neuroprotection is the most important part of post-resuscitation therapy. The goals of the neuroprotection tools available today are preventing the evolution of primary and formation of secondary brain injury. We are going to summarize the neuroprotective possibilities that we can reach today. We will discuss the role of pharmacologic strategies including sedation, the modalities of upholding brain perfusion, the monitoring of proper hemodynamic variables and the practice of targeted temperature management. It is very important to avoid hypo- A nd hyperoxia, to keep normocapnia, normoglycemia and to control seizures during the management of post-cardiac arrest patients. There is still a lack of evidence to prove which pharmacologic agent may be effective in postresuscitation neuroprotection, however, there are some promising results regarding thiamine. Hemodynamic management guided by higher level hemodynamic monitoring may be beneficial in enhancing brain perfusion but more clinical studies are needed to investigate its usefulness. Targeted temperature management constitutes the main element of post-resuscitation neuroprotection, however, the details of its implementation raise several questions.",
keywords = "Brain injury, Cardiopulmonary resuscitation, Neuroprotection",
author = "Kov{\'a}cs Eniko and G{\'a}l J{\'a}nos and Merkely B{\'e}la and Zima Endre",
year = "2019",
month = "1",
day = "1",
doi = "10.1556/650.2019.31589",
language = "Hungarian",
volume = "160",
pages = "1832--1839",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "46",

}

TY - JOUR

T1 - A postresuscitatiós ellátás neuroprotekciós lehetoségei 2019-ben

AU - Eniko, Kovács

AU - János, Gál

AU - Béla, Merkely

AU - Endre, Zima

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Post-resuscitation brain injury forms the leading cause of death of patients after successful cardiopulmonary resuscitation that explains why post-resuscitation neuroprotection is the most important part of post-resuscitation therapy. The goals of the neuroprotection tools available today are preventing the evolution of primary and formation of secondary brain injury. We are going to summarize the neuroprotective possibilities that we can reach today. We will discuss the role of pharmacologic strategies including sedation, the modalities of upholding brain perfusion, the monitoring of proper hemodynamic variables and the practice of targeted temperature management. It is very important to avoid hypo- A nd hyperoxia, to keep normocapnia, normoglycemia and to control seizures during the management of post-cardiac arrest patients. There is still a lack of evidence to prove which pharmacologic agent may be effective in postresuscitation neuroprotection, however, there are some promising results regarding thiamine. Hemodynamic management guided by higher level hemodynamic monitoring may be beneficial in enhancing brain perfusion but more clinical studies are needed to investigate its usefulness. Targeted temperature management constitutes the main element of post-resuscitation neuroprotection, however, the details of its implementation raise several questions.

AB - Post-resuscitation brain injury forms the leading cause of death of patients after successful cardiopulmonary resuscitation that explains why post-resuscitation neuroprotection is the most important part of post-resuscitation therapy. The goals of the neuroprotection tools available today are preventing the evolution of primary and formation of secondary brain injury. We are going to summarize the neuroprotective possibilities that we can reach today. We will discuss the role of pharmacologic strategies including sedation, the modalities of upholding brain perfusion, the monitoring of proper hemodynamic variables and the practice of targeted temperature management. It is very important to avoid hypo- A nd hyperoxia, to keep normocapnia, normoglycemia and to control seizures during the management of post-cardiac arrest patients. There is still a lack of evidence to prove which pharmacologic agent may be effective in postresuscitation neuroprotection, however, there are some promising results regarding thiamine. Hemodynamic management guided by higher level hemodynamic monitoring may be beneficial in enhancing brain perfusion but more clinical studies are needed to investigate its usefulness. Targeted temperature management constitutes the main element of post-resuscitation neuroprotection, however, the details of its implementation raise several questions.

KW - Brain injury

KW - Cardiopulmonary resuscitation

KW - Neuroprotection

UR - http://www.scopus.com/inward/record.url?scp=85074741987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074741987&partnerID=8YFLogxK

U2 - 10.1556/650.2019.31589

DO - 10.1556/650.2019.31589

M3 - Article

C2 - 31707820

AN - SCOPUS:85074741987

VL - 160

SP - 1832

EP - 1839

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 46

ER -