Az antioxidáns therapia lehetöségei az amiodaron mellékhatások megelözésében, illetve kivédésében.

Translated title of the contribution: Possibilities of antioxidant therapy in the prevention of side effects of amiodarone

A. Vereckei, E. Fehér, I. György, G. Fóldiák, M. Tóth, H. Toncsev, J. Fehér

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The authors demonstrated the generation of a very reactive phenyl radical from amiodarone in a reducing molecular environment by pulse radiolysis study. The various antioxidants are probably not capable of preventing the generation of phenyl radical, as well as to protect against its damaging effects on the neighboring molecules. Electron microscopic studies from lung tissue of in vivo treated rats showed that the simultaneous Silibinin (a flavonoid type antioxidant) treatment with amiodarone decreased significantly the lysosomal phospholipoidosis induced by amiodarone compared with the amiodarone treated group, but it didn't prevent entirely the accumulation of lysosomal phospholipids. The in vitro lysosomal beta-glucuronidase enzyme release measured from the liver tissue of in vivo treated rats increased significantly on amiodarone treatment, the antioxidants used (Silibinin, and the dihydroquinoline type MTDQ-DA) didn't exert any favorable effect. The authors discuss in details the possible relationships between free radical reactions and lysosomal phospholipoidosis.

Original languageHungarian
Pages (from-to)1265-1268
Number of pages4
JournalOrvosi Hetilap
Volume132
Issue number23
Publication statusPublished - Jun 9 1991

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Amiodarone
Antioxidants
Pulse Radiolysis
Therapeutics
Glucuronidase
Flavonoids
Free Radicals
Phospholipids
Electrons
Lung
Liver
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az antioxidáns therapia lehetöségei az amiodaron mellékhatások megelözésében, illetve kivédésében. / Vereckei, A.; Fehér, E.; György, I.; Fóldiák, G.; Tóth, M.; Toncsev, H.; Fehér, J.

In: Orvosi Hetilap, Vol. 132, No. 23, 09.06.1991, p. 1265-1268.

Research output: Contribution to journalArticle

Vereckei, A, Fehér, E, György, I, Fóldiák, G, Tóth, M, Toncsev, H & Fehér, J 1991, 'Az antioxidáns therapia lehetöségei az amiodaron mellékhatások megelözésében, illetve kivédésében.', Orvosi Hetilap, vol. 132, no. 23, pp. 1265-1268.
Vereckei A, Fehér E, György I, Fóldiák G, Tóth M, Toncsev H et al. Az antioxidáns therapia lehetöségei az amiodaron mellékhatások megelözésében, illetve kivédésében. Orvosi Hetilap. 1991 Jun 9;132(23):1265-1268.
Vereckei, A. ; Fehér, E. ; György, I. ; Fóldiák, G. ; Tóth, M. ; Toncsev, H. ; Fehér, J. / Az antioxidáns therapia lehetöségei az amiodaron mellékhatások megelözésében, illetve kivédésében. In: Orvosi Hetilap. 1991 ; Vol. 132, No. 23. pp. 1265-1268.
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