A tumorindukált angiogenezis gátlásának lehetõségei

eredmények multi-target tirozinkináz- gátlókkal

Translated title of the contribution: Possibilities for inhibiting tumor-induced angiogenesis: Results with multi-target tyrosine kinase inhibitors

Török Szilvia, B. Döme

Research output: Contribution to journalArticle

Abstract

Functional blood vasculature is essential for tumor progression. The main signalization pathways that play a key role in the survival and growth of tumor vessels originate from the VEGF-, PDGF- and FGF tyrosine kinase receptors. In the past decade, significant results have been published on receptor tyrosine kinase inhibitors (RTKIs). In this paper, the mechanisms of action and the results so far available of experimental and clinical studies on multi-target antiangiogenic TKIs are discussed. On the one hand, notable achievements have been made recently and these drugs are already used in clinical practice in some patient populations. On the other hand, the optimal combination and dosage of these drugs, selection of the apropriate biomarker and better understanding of the conflicting role of PDGFR and FGFR signaling in angiogenesis remain future challenges.

Original languageHungarian
Pages (from-to)3-15
Number of pages13
JournalMagyar Onkologia
Volume56
Issue number1
Publication statusPublished - 2012

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Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
Drug Combinations
Vascular Endothelial Growth Factor A
Neoplasms
Biomarkers
Survival
Growth
Pharmaceutical Preparations
Population
PDGF receptor tyrosine kinase
Clinical Studies

ASJC Scopus subject areas

  • Oncology

Cite this

A tumorindukált angiogenezis gátlásának lehetõségei : eredmények multi-target tirozinkináz- gátlókkal. / Szilvia, Török; Döme, B.

In: Magyar Onkologia, Vol. 56, No. 1, 2012, p. 3-15.

Research output: Contribution to journalArticle

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