Possibilities and results in the wide-scale genomic analysis of inflammation: Looking for the child among many midwives

A. K. Fülöp, A. Falus

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Only recently, available microarray methods have been extended to the investigation of such complex pathophysiological conditions as inflammatory disease. Genome analysis gives the possibility of looking for susceptibility gene loci and their allelic combinations. By the analysis of mRNAs (transcriptome), novel players, functional groups of participants and regulatory pathways involved in the inflammation can be revealed. The possibility of comparing several samples is ideal to increase our knowledge about the kinetics of inflammation. The effects and post-receptor signalling events of individual pro- or anti-inflammatory mediators can also be tested. The use of human post mortem samples could yield otherwise inaccessible information on molecular mechanisms of chronic inflammatory diseases. However, the analysis and interpretation of a huge amount of data, the selection of appropriate experimental systems and time points may hide some pitfalls, which emphasize the need to confirm results with independent methods such as e.g. semi-quantitative Northern, real time PCR, RNA-ase protection assay as well as functional studies.

Original languageEnglish
Pages (from-to)517-522
Number of pages6
JournalInflammation Research
Volume53
Issue number10
DOIs
Publication statusPublished - Oct 1 2004

Keywords

  • Genome-wide analyses
  • Inflammation
  • Inflammatory acute phase proteins

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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