Positive reinforcing effects of substance P in the rat globus pallidus revealed by conditioned place preference

Erika Kertes, Kristóf László, Beáta Berta, László Lénárd

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Substance P (SP) may have positive reinforcing effects when injected into different brain structures. Immunohistochemical experiments showed the presence of SP-immunoreactive fibers and also its receptors in the globus pallidus (GP). According to recent experimental data the GP may be involved in reward-related processes.The aim of our study was to test possible rewarding consequences of pallidal SP in conditioned place preference (CPP) paradigm. Male Wistar rats, microinjected with 10. ng SP, showed place preference, while 100. ng SP had no such positive reinforcing effect. The possible involvement of NK1 receptors was also studied. Prior treatment with the NK1 receptor antagonist WIN 51,708 could block the rewarding effects of SP, while the antagonist on its own did not influence CPP behavior. Our results show that SP and its NK1 receptors play important roles in pallidal positive reinforcing mechanisms.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalBehavioural Brain Research
Volume215
Issue number1
DOIs
Publication statusPublished - Dec 1 2010

Keywords

  • Conditioned place preference
  • Globus pallidus
  • NK1 receptor
  • Reward
  • Substance P

ASJC Scopus subject areas

  • Behavioral Neuroscience

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