Positive reinforcing effects of RFamide-related peptide-1 in the rat central nucleus of amygdala

L. Lénárd, Anita Kova´cs, Tama´s Ollmann, La´szlo´ Pe´czely, Olga Zagoracz, Rita Ga´losi, Kristo´f La´szlo´

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The amygdaloid body (AMY) plays an important role in memory, learning and reward-related processes. RFamide-related peptide-1 (RFRP-1) immunoreactive fibers and NPFF1 receptors were identified in the AMY, and previously we verified that neuropeptide RFRP-1 infused into the central nucleus of AMY (CeA) caused food intake decrease. The aim of the present study was to examine the possible rewarding or aversive effects of RFRP-1 in the CeA. In conditioned place preference, test male Wistar rats were microinjected bilaterally with 50 or 100. ng RFRP-1 in volume of 0.4. μl. In other groups of animals, 20. ng NPFF receptor antagonist RF9 was applied or the antagonist was used 15. min before 50. ng RFRP-1 treatment. Fifty nanograms of RFRP-1 had positive reinforcing properties, while 100. ng RFRP-1 had no effect. Prior treatment with NPFF receptor antagonist RF9 could block the rewarding effects of RFRP-1, while the antagonist applied alone did not influence the behavior of rats in place preference paradigm. Our results show that RFRP-1 and NPFF-1 receptors play important roles in the amygdaloid rewarding-reinforcing mechanisms.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalBehavioural Brain Research
Volume275
DOIs
Publication statusPublished - Sep 3 2014

Fingerprint

Amygdala
Central Amygdaloid Nucleus
RFamide peptide
Neuropeptides
Reward
Wistar Rats
Eating
Learning
neuropeptide FF receptor

Keywords

  • Amygdala
  • NPFF receptor antagonist RF9
  • Place preference
  • Reinforcement
  • RFRP-1

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Positive reinforcing effects of RFamide-related peptide-1 in the rat central nucleus of amygdala. / Lénárd, L.; Kova´cs, Anita; Ollmann, Tama´s; Pe´czely, La´szlo´; Zagoracz, Olga; Ga´losi, Rita; La´szlo´, Kristo´f.

In: Behavioural Brain Research, Vol. 275, 03.09.2014, p. 101-106.

Research output: Contribution to journalArticle

Lénárd, L, Kova´cs, A, Ollmann, T, Pe´czely, L, Zagoracz, O, Ga´losi, R & La´szlo´, K 2014, 'Positive reinforcing effects of RFamide-related peptide-1 in the rat central nucleus of amygdala', Behavioural Brain Research, vol. 275, pp. 101-106. https://doi.org/10.1016/j.bbr.2014.08.051
Lénárd, L. ; Kova´cs, Anita ; Ollmann, Tama´s ; Pe´czely, La´szlo´ ; Zagoracz, Olga ; Ga´losi, Rita ; La´szlo´, Kristo´f. / Positive reinforcing effects of RFamide-related peptide-1 in the rat central nucleus of amygdala. In: Behavioural Brain Research. 2014 ; Vol. 275. pp. 101-106.
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