Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart

Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

Rosalinda Madonna, Linda W. Van Laake, Sean M. Davidson, Felix B. Engel, Derek J. Hausenloy, Sandrine Lecour, Jonathan Leor, Cinzia Perrino, Rainer Schulz, Kirsti Ytrehus, Ulf Landmesser, Christine L. Mummery, Stefan Janssens, James Willerson, Thomas Eschenhagen, P. Ferdinándy, Joost P G Sluijter

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.

Original languageEnglish
Pages (from-to)1789-1798
Number of pages10
JournalEuropean Heart Journal
Volume37
Issue number23
DOIs
Publication statusPublished - Jun 14 2016

Fingerprint

Cell- and Tissue-Based Therapy
Myocardial Ischemia
Cell Biology
Regeneration
Heart Failure
Therapeutics
Biocompatible Materials
Genetic Therapy
Clinical Trials
Morbidity
Muscles
Mortality

Keywords

  • Cell-based therapy
  • Heart Failure
  • Heart Regeneration
  • Heart repair
  • Ischaemic heart disease

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart : Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. / Madonna, Rosalinda; Van Laake, Linda W.; Davidson, Sean M.; Engel, Felix B.; Hausenloy, Derek J.; Lecour, Sandrine; Leor, Jonathan; Perrino, Cinzia; Schulz, Rainer; Ytrehus, Kirsti; Landmesser, Ulf; Mummery, Christine L.; Janssens, Stefan; Willerson, James; Eschenhagen, Thomas; Ferdinándy, P.; Sluijter, Joost P G.

In: European Heart Journal, Vol. 37, No. 23, 14.06.2016, p. 1789-1798.

Research output: Contribution to journalReview article

Madonna, R, Van Laake, LW, Davidson, SM, Engel, FB, Hausenloy, DJ, Lecour, S, Leor, J, Perrino, C, Schulz, R, Ytrehus, K, Landmesser, U, Mummery, CL, Janssens, S, Willerson, J, Eschenhagen, T, Ferdinándy, P & Sluijter, JPG 2016, 'Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure', European Heart Journal, vol. 37, no. 23, pp. 1789-1798. https://doi.org/10.1093/eurheartj/ehw113
Madonna, Rosalinda ; Van Laake, Linda W. ; Davidson, Sean M. ; Engel, Felix B. ; Hausenloy, Derek J. ; Lecour, Sandrine ; Leor, Jonathan ; Perrino, Cinzia ; Schulz, Rainer ; Ytrehus, Kirsti ; Landmesser, Ulf ; Mummery, Christine L. ; Janssens, Stefan ; Willerson, James ; Eschenhagen, Thomas ; Ferdinándy, P. ; Sluijter, Joost P G. / Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart : Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. In: European Heart Journal. 2016 ; Vol. 37, No. 23. pp. 1789-1798.
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