Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1)

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

MRP1 (ABCC1) is a peculiar member of the ABC transporter superfamily for several aspects. This protein has an unusually broad substrate specificity and is capable of transporting not only a wide variety of neutral hydrophobic compounds, like the MDR1/P-glycoprotein, but also facilitating the extrusion of numerous glutathione, glucuronate, and sulfate conjugates. The transport mechanism of MRP1 is also complex; a composite substrate-binding site permits both cooperativity and competition between various substrates. This versatility and the ubiquitous tissue distribution make this transporter suitable for contributing to various physiological functions, including defense against xenobiotics and endogenous toxic metabolites, leukotriene-mediated inflammatory responses, as well as protection from the toxic effect of oxidative stress. In this paper, we give an overview of the considerable amount of knowledge which has accumulated since the discovery of MRP1 in 1992. We place special emphasis on the structural features essential for function, our recent understanding of the transport mechanism, and the numerous assignments of this transporter.

Original languageEnglish
Pages (from-to)621-641
Number of pages21
JournalPflugers Archiv European Journal of Physiology
Volume453
Issue number5
DOIs
Publication statusPublished - Feb 1 2007

Keywords

  • ABC transporter
  • Cancer drug resistance
  • Detoxification
  • Glutathione conjugates
  • Multidrug resistance
  • Multispecific organic anion transporter
  • Xenobiotic transport

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1)'. Together they form a unique fingerprint.

  • Cite this