Porphyrin synthesis in primary nervous tissue cultures from 10-3 M delta-aminolaevulinic acid in the presence of melatonin and neuropeptides

Irene Durkó, A. Juhász

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9 Citations (Scopus)

Abstract

Of the primary neuronal tissue cultures (glia cell, neuronal cells, mixed and retina cultures), the neuronal cells of (cells + medium) display the highest total porphyrin production from 10-3 M delta-aminolaevulinic acid (ALA). In the presence of 10-3-10-6 M melatonin, the quantity of total prophyrins produced by the neuronal cultures decreases in inverse proportion to the concentration. Oxytocin, lysine-vasopressin, CCK-8 sulphate ester and des-Tyr-gamma-endorphin in concentrations of 10-5 and 10-6 M block the porphyrin synthesis of the glia cells and display different effects on that of the neuronal cells. They enhance the total porphyrin synthesis of the cell cultures, with the exception of 10-5 M des-Tyr-gamma-endorphin, which exerts an inhibitory effect on the glia cells.

Original languageEnglish
Pages (from-to)607-615
Number of pages9
JournalNeurochemical Research
Volume11
Issue number5
DOIs
Publication statusPublished - May 1986

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Nerve Tissue
Tissue culture
Aminolevulinic Acid
Porphyrins
gamma-Endorphin
Melatonin
Neuropeptides
Neuroglia
Lypressin
Cell Culture Techniques
Oxytocin
Cell culture
Esters
Retina

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

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