Porphyrinstoffwechsel-und klinisch-laboratoriumsmäßige Untersuchungen in Modellversuchen und an Patienten mit Porphyria cutanea tarda

Translated title of the contribution: Porphyria cutanea tarda: Comparative investigations on porphyrin metabolism and experimental liver poisoning

N. Simon, A. Dobozy, Gy Berkó

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. In Hexachlorobenzol (HCB) poisoned rats both the DALA synthetase activity of the liver and the total amount of the porphyrine excreted in the urine are simultaneously increased. 2. The activity of the DALA synthetase in the liver continues to increase for several months even after the HCB administration has been abolished. 3. The distribution pattern of the porphyrine fractions excreted in the urine of the HCB-poisoned rats resembles to a great extent that of patients suffering from PCT. 4. The porphyrines containing in sequence the 8, 7 and 6 carboxyl groups are stored in the liver and kidneys. 5. Transaminases and A/G quotient in the animals poisoned with HCB as well as in the patients suffering from PCT showed similar pathologic values. 6. In the poisoned rats and in the PCT patients the amount of the DALA excreted in the urine was only slightly increased.

Original languageGerman
Pages (from-to)38-43
Number of pages6
JournalArchiv für Klinische und Experimentelle Dermatologie
Volume238
Issue number1
DOIs
Publication statusPublished - Mar 1970

Fingerprint

Porphyria Cutanea Tarda
Porphyrins
Poisoning
Urine
Ligases
Liver
Transaminases
Kidney
Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

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title = "Porphyrinstoffwechsel-und klinisch-laboratoriumsm{\"a}{\ss}ige Untersuchungen in Modellversuchen und an Patienten mit Porphyria cutanea tarda",
abstract = "1. In Hexachlorobenzol (HCB) poisoned rats both the DALA synthetase activity of the liver and the total amount of the porphyrine excreted in the urine are simultaneously increased. 2. The activity of the DALA synthetase in the liver continues to increase for several months even after the HCB administration has been abolished. 3. The distribution pattern of the porphyrine fractions excreted in the urine of the HCB-poisoned rats resembles to a great extent that of patients suffering from PCT. 4. The porphyrines containing in sequence the 8, 7 and 6 carboxyl groups are stored in the liver and kidneys. 5. Transaminases and A/G quotient in the animals poisoned with HCB as well as in the patients suffering from PCT showed similar pathologic values. 6. In the poisoned rats and in the PCT patients the amount of the DALA excreted in the urine was only slightly increased.",
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T1 - Porphyrinstoffwechsel-und klinisch-laboratoriumsmäßige Untersuchungen in Modellversuchen und an Patienten mit Porphyria cutanea tarda

AU - Simon, N.

AU - Dobozy, A.

AU - Berkó, Gy

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N2 - 1. In Hexachlorobenzol (HCB) poisoned rats both the DALA synthetase activity of the liver and the total amount of the porphyrine excreted in the urine are simultaneously increased. 2. The activity of the DALA synthetase in the liver continues to increase for several months even after the HCB administration has been abolished. 3. The distribution pattern of the porphyrine fractions excreted in the urine of the HCB-poisoned rats resembles to a great extent that of patients suffering from PCT. 4. The porphyrines containing in sequence the 8, 7 and 6 carboxyl groups are stored in the liver and kidneys. 5. Transaminases and A/G quotient in the animals poisoned with HCB as well as in the patients suffering from PCT showed similar pathologic values. 6. In the poisoned rats and in the PCT patients the amount of the DALA excreted in the urine was only slightly increased.

AB - 1. In Hexachlorobenzol (HCB) poisoned rats both the DALA synthetase activity of the liver and the total amount of the porphyrine excreted in the urine are simultaneously increased. 2. The activity of the DALA synthetase in the liver continues to increase for several months even after the HCB administration has been abolished. 3. The distribution pattern of the porphyrine fractions excreted in the urine of the HCB-poisoned rats resembles to a great extent that of patients suffering from PCT. 4. The porphyrines containing in sequence the 8, 7 and 6 carboxyl groups are stored in the liver and kidneys. 5. Transaminases and A/G quotient in the animals poisoned with HCB as well as in the patients suffering from PCT showed similar pathologic values. 6. In the poisoned rats and in the PCT patients the amount of the DALA excreted in the urine was only slightly increased.

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