1. In Hexachlorobenzol (HCB) poisoned rats both the DALA synthetase activity of the liver and the total amount of the porphyrine excreted in the urine are simultaneously increased. 2. The activity of the DALA synthetase in the liver continues to increase for several months even after the HCB administration has been abolished. 3. The distribution pattern of the porphyrine fractions excreted in the urine of the HCB-poisoned rats resembles to a great extent that of patients suffering from PCT. 4. The porphyrines containing in sequence the 8, 7 and 6 carboxyl groups are stored in the liver and kidneys. 5. Transaminases and A/G quotient in the animals poisoned with HCB as well as in the patients suffering from PCT showed similar pathologic values. 6. In the poisoned rats and in the PCT patients the amount of the DALA excreted in the urine was only slightly increased.
|Translated title of the contribution||Porphyria cutanea tarda: Comparative investigations on porphyrin metabolism and experimental liver poisoning|
|Number of pages||6|
|Journal||Archiv für Klinische und Experimentelle Dermatologie|
|Publication status||Published - Mar 1 1970|
ASJC Scopus subject areas