Population surveillance of sentinel anolalies

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Three types of indicator conditions, namely sentinel anomalies, Down syndriome and pair-wise evaluation of component congenital anomalies in unidentified multiple congenital abnormalities, are evaluated continously in Hungary. This paper summarizes some data of the Hungarian Surveillance of Sentinel Anomalies (1980-1987). The observed rate of 15 sentinel anomalies was 3.7 per 10,000 live births. An average of 35 new mutations per 100,000 live births was found annually. This database is database is appropriate for the estimation of mutation rates in these sentinel anomalies. The mean maternal age did not differe significantly in comparisons of either sporadic vs. familial cases or sporadic vs. matched control cases. However, the mean paternal age was significantly higher in the sporadic cases than in the familial and matched control cases. The analysis of environmental histories in sporadic cases is in progress.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume212
Issue number1
DOIs
Publication statusPublished - 1989

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Population Surveillance
Live Birth
Paternal Age
Sentinel Surveillance
Databases
Multiple Abnormalities
Hungary
Maternal Age
Mutation Rate
Mutation
cyhalothrin

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Population surveillance of sentinel anolalies. / Czeizel, E.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 212, No. 1, 1989, p. 3-9.

Research output: Contribution to journalArticle

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