Population expression of HLA*02 subtypes indicates a common origin for North Indians and Hungarian Gypsies

K. Rajczy, R. Jaini, L. Kereszturi, E. Pozsonyi, K. Garaczi, G. Kaur, E. Gyodi, N. K. Mehra, G. Petrányi

Research output: Contribution to journalArticle

Abstract

HLA*02 is known to be the most abundant allele in the majority of populations with a phenotype frequency ranging from 20-60%. The HLA-A*02 allele family has 51 subtypes reported. The high prevalence and immense polymorphism in this allele family indicates a major functional significance in the genome. We have investigated the IILA-A*02 subtype repertoire in three populations: the North Indians (n=78), Hungarian Magyars (n=55) and Hungarian Gypsies (n=17). The Hungarian Gypsy population studied is a relatively homogeneous population since for social reasons less cross mating with local Magyar population were recognized as suspected. The phenotype frequency of HLA-A locus alleles shows a high predominance of HLA-A2 in all populations, thus the allele is represented at a phenotype frequency of 34.9% among the North Indians, 45.8% in the Hungarian Magyars and 40% in the Hungarian Gypsies. Subtyping data indicates that A*0201, the typical Caucasoid allele is also prevalent in the Hungarian Magyars (96.4%) and Hungarian Gypsies (82.3%). In contrast, among the North Indians A*0201 is seen at negligible frequencies (3%). Subtype distribution revealed that in the Hungarian Magyars only two subtypes of HLA*02 were evident, A*0201 (>95%) and A*0205(

Original languageEnglish
Pages (from-to)279
Number of pages1
JournalEuropean Journal of Immunogenetics
Volume28
Issue number2
Publication statusPublished - 2001

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Roma
Alleles
Population
HLA-A Antigens
Phenotype
HLA-A2 Antigen
Genome

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Population expression of HLA*02 subtypes indicates a common origin for North Indians and Hungarian Gypsies. / Rajczy, K.; Jaini, R.; Kereszturi, L.; Pozsonyi, E.; Garaczi, K.; Kaur, G.; Gyodi, E.; Mehra, N. K.; Petrányi, G.

In: European Journal of Immunogenetics, Vol. 28, No. 2, 2001, p. 279.

Research output: Contribution to journalArticle

Rajczy, K, Jaini, R, Kereszturi, L, Pozsonyi, E, Garaczi, K, Kaur, G, Gyodi, E, Mehra, NK & Petrányi, G 2001, 'Population expression of HLA*02 subtypes indicates a common origin for North Indians and Hungarian Gypsies', European Journal of Immunogenetics, vol. 28, no. 2, pp. 279.
Rajczy, K. ; Jaini, R. ; Kereszturi, L. ; Pozsonyi, E. ; Garaczi, K. ; Kaur, G. ; Gyodi, E. ; Mehra, N. K. ; Petrányi, G. / Population expression of HLA*02 subtypes indicates a common origin for North Indians and Hungarian Gypsies. In: European Journal of Immunogenetics. 2001 ; Vol. 28, No. 2. pp. 279.
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