Poor clinical outcome in early stage cervical cancer with human papillomavirus-18 positive lymph nodes

Tamás Sápy, Z. Hernádi, József Kónya, Lóránd Lukácskó

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Epidemiologic and molecular studies have proven that human papillomavirus (HPV) plays an important role in the development of cervical cancer. However, the role of the virus in the progression of the disease, i.e. in the development of lymph node metastasis and in the adverse clinical outcome is poorly understood. We have been using the polymerase chain reaction (PCR) to study the presence and typing of human papillomavirus DNA since 1980 in cervical cancers and pelvic lymph nodes from the same patients. Out of the series of 47 cervical cancer patients we focused on four women (age: 41, 33, 35 and 56 years) in this article. The follow-up of these patients revealed early recurrences of the disease (7, 7, 17, 22 months) with very short survival (9, 10, 21, 24 months). Although we detected HPV-18 positivity both in the cervical tumors and in the regional lymph nodes too in all four cases, lymph nodes were negative by routine hystology in case of the three young patients (21, 33, 35 years of age). Our observations suggest that HPV type 18 positive cervical cancer patients, despite negative histological findings in the lymph nodes should be consider as a subpopulation for poor outcome especially in the young age group (p=0,022, Fisher's exact test). Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume90
Issue number1
DOIs
Publication statusPublished - May 2000

Fingerprint

Human papillomavirus 18
Uterine Cervical Neoplasms
Lymph Nodes
Disease Progression
Epidemiologic Studies
Age Groups
Neoplasm Metastasis
Viruses
Recurrence
Polymerase Chain Reaction
Survival
DNA
Neoplasms

Keywords

  • Cervical cancer
  • Human papillomavirus
  • Poor prognosis
  • Young-age

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Poor clinical outcome in early stage cervical cancer with human papillomavirus-18 positive lymph nodes. / Sápy, Tamás; Hernádi, Z.; Kónya, József; Lukácskó, Lóránd.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 90, No. 1, 05.2000, p. 93-95.

Research output: Contribution to journalArticle

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