Pooling analysis of genetic data: Heat shock protein HSPA1B (1267)G allele: A possible selection factor for civilization diseases?

Andrea Fekete, Attila J. Szabó, Nora F. Banki, B. Györffy, T. Tulassay, B. Vásárhelyi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction: A large amount of data published during the last decade support the central role of heat shock proteins (HSP)70s in cellular defense under various forms of stress situations. HSPA1B genetic polymorphisms have been suggested to have an impact on the production of HSP70s. Interestingly our previous studies along with other observations indicate that genotype distribution of HSPA1B A(1267)G is skewed toward HSPA1B (1267)A carriers in the majority of studies enrolling healthy people. This suggests that this genetic polymorphism may be associated with the general health status. Methods: In the present study we tested this theory using our database containing HSPA1B A(1267)G genotype data of 550 healthy subjects of different ages (0-65ys) and performed a meta-analysis of genotypes published by other studies enrolling 2000 subjects. Results: Our results show that HSPA1B A(1267)G genotype distribution fulfills Hardy-Weinberg criteria in full-term neonates, in healthy blood donors under 35 ys of age and in unselected group of random controls. On the other hand, genotype distributions deviated significantly from the expected one in each study investigating healthy blood donors older than 35 years; in this population the prevalence of HSPA1B (1267)GG genotype was the lowest, about 8%. Conclusion: This finding supports that carrier state of HSPA1B (1267)G allele might be associated with general health status in older patients and may be a factor that is responsible for the dropout of potential blood donors from the ageing overall population.

Original languageEnglish
Title of host publicationHeat Shock Proteins: New Research
PublisherNova Science Publishers, Inc.
Pages153-163
Number of pages11
ISBN (Print)9781604566413
Publication statusPublished - Mar 2008

Fingerprint

Civilization
Heat-Shock Proteins
Blood
Alleles
Genotype
Polymorphism
Blood Donors
Health
Genetic Polymorphisms
Health Status
Aging of materials
Carrier State
Population
Meta-Analysis
Healthy Volunteers
Newborn Infant
Databases
Control Groups

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fekete, A., Szabó, A. J., Banki, N. F., Györffy, B., Tulassay, T., & Vásárhelyi, B. (2008). Pooling analysis of genetic data: Heat shock protein HSPA1B (1267)G allele: A possible selection factor for civilization diseases? In Heat Shock Proteins: New Research (pp. 153-163). Nova Science Publishers, Inc..

Pooling analysis of genetic data : Heat shock protein HSPA1B (1267)G allele: A possible selection factor for civilization diseases? / Fekete, Andrea; Szabó, Attila J.; Banki, Nora F.; Györffy, B.; Tulassay, T.; Vásárhelyi, B.

Heat Shock Proteins: New Research. Nova Science Publishers, Inc., 2008. p. 153-163.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fekete, A, Szabó, AJ, Banki, NF, Györffy, B, Tulassay, T & Vásárhelyi, B 2008, Pooling analysis of genetic data: Heat shock protein HSPA1B (1267)G allele: A possible selection factor for civilization diseases? in Heat Shock Proteins: New Research. Nova Science Publishers, Inc., pp. 153-163.
Fekete A, Szabó AJ, Banki NF, Györffy B, Tulassay T, Vásárhelyi B. Pooling analysis of genetic data: Heat shock protein HSPA1B (1267)G allele: A possible selection factor for civilization diseases? In Heat Shock Proteins: New Research. Nova Science Publishers, Inc. 2008. p. 153-163
Fekete, Andrea ; Szabó, Attila J. ; Banki, Nora F. ; Györffy, B. ; Tulassay, T. ; Vásárhelyi, B. / Pooling analysis of genetic data : Heat shock protein HSPA1B (1267)G allele: A possible selection factor for civilization diseases?. Heat Shock Proteins: New Research. Nova Science Publishers, Inc., 2008. pp. 153-163
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