Polyvinylpyrolidone as carrier to prepare solid disperssion-pros and cons

Rita Ambrus, Ágnes Nacsa, P. Szabó-Révész, Z. Aigner, Simona Cinta-Panzaru

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Enhancement of the solubility of poorly-soluble drug substances is one of the most important tasks in pharmaceutical technology. It is possible to solve this problem with new drug carrier systems and/or with new technological processes. The solid dispersion technology is generally accepted technique which is able to enhance the dissolution characteristics of drugs with poor water solubility. For this purpose, the drug substance is dispersed in a water-soluble inert polymer matrix; at the higher surface area, due to the presence of the polymer, sometimes the drug solubility and dissolution rate may increase. This work summarizes the theoretical basics of solid dispersion technology and introduces pros and cons of studies using polyvinylpyrrolidone (PVP) as a carrier in the cases of two chosen active pharmaceutical ingredients (APIs), nifluminic acid (NIF) and loratadine (LOR). Wettability properties and dissolution were characterized. The drug-polymer interaction was investigated by using differential scanning calorimetry, and powder X-ray diffraction. Even though the instrumental examinations show similar results for both drugs, the dissolution rate improved only by NIF significantly. The explanation for this phenomena could be sought in the different chemical structure and the strength of the connection between the PVP and the drugs.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
JournalRevista de Chimie
Volume60
Issue number6
Publication statusPublished - 2009

Fingerprint

Pharmaceutical Preparations
Dissolution
Povidone
Solubility
Polymers
Loratadine
Drug Carriers
Acids
Water
Polymer matrix
X ray powder diffraction
Wetting
Differential scanning calorimetry

Keywords

  • Dissolution
  • DSC
  • Loratadine
  • Nifluminic acid
  • Polyvinylpyrrolidone
  • Solid dispersion
  • X-ray

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Polyvinylpyrolidone as carrier to prepare solid disperssion-pros and cons. / Ambrus, Rita; Nacsa, Ágnes; Szabó-Révész, P.; Aigner, Z.; Cinta-Panzaru, Simona.

In: Revista de Chimie, Vol. 60, No. 6, 2009, p. 539-543.

Research output: Contribution to journalArticle

Ambrus, Rita ; Nacsa, Ágnes ; Szabó-Révész, P. ; Aigner, Z. ; Cinta-Panzaru, Simona. / Polyvinylpyrolidone as carrier to prepare solid disperssion-pros and cons. In: Revista de Chimie. 2009 ; Vol. 60, No. 6. pp. 539-543.
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