Polyunsaturated fatty acids in plasma lipids of obese children with and without metabolic cardiovascular syndrome

T. Decsi, G. Csabi, K. Torok, E. Erhardt, H. Minda, I. Burus, S. Molnar, D. Molnár

Research output: Contribution to journalArticle

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Abstract

Previously we reported significantly higher values of γ-linolenic acid (GLA, 18:3n-6), dihomo-γ-linolenic acid (DHGLA, 20:3n-6), and arachidonic acid (20:4n-6) in plasma lipid classes in obese children than in nonobese controls. In the present study, fatty acid composition of plasma phospholipids (PL) and sterol esters (STE) was determined by high-resolution capillary gas-liquid chromatography in obese children with and without metabolic cardiovascular syndrome [MCS: defined as simultaneous presence of (i) dyslipidemia, (ii) hyperinsulinemia, (iii) hypertension, and (iv) impaired glucose tolerance] and in nonobese controls. Fatty acid composition of PL and STE lipids did not differ between obese children without MCS and controis. Obese children with MCS exhibited significantly lower linoleic acid (LA, 18:2n-6) values in PL (17.43 [2.36], % wt/wt, median [range from the first to the third quartile]) than obese children without MCS (19.14 [3.49]) and controls (20.28 [3.80]). In contrast, PL GLA values were significantly higher in obese children with (0.13 [0.08]) than in those without MCS (0.08 [0.04]), whereas STE GLA values were higher in obese children with MCS (1.04 [0.72]) than in controls (0.62 [0.481). DHGLA values in PL were significantly higher in obese children with MCS (4.06 [0.741) than in controls (2.69 [1.60]). The GLA/LA ratio was significantly higher, whereas the AA/DHGLA ratio was significantly lower in obese children with MCS than in obese children without MCS and in controls. In this study, LA metabolism was affected only in obese children with but not in those without MCS. In obese children with MCS, Δ6-desaturase activity appeared to be stimulated, whereas Δ5-desaturase activity appeared to be inhibited. Disturbances in LA metabolism may represent an additional health hazard within the multifaceted clinical picture of MCS.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalLipids
Volume35
Issue number11
Publication statusPublished - 2000

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Metabolic Syndrome X
Unsaturated Fatty Acids
blood lipids
polyunsaturated fatty acids
Phospholipids
Lipids
Plasmas
Sterols
Esters
alpha-Linolenic Acid
phospholipids
sterol esters
Metabolism
Fatty Acids
Health hazards
Liquid chromatography
Linoleic Acid
linolenic acid
Chemical analysis
Arachidonic Acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

Polyunsaturated fatty acids in plasma lipids of obese children with and without metabolic cardiovascular syndrome. / Decsi, T.; Csabi, G.; Torok, K.; Erhardt, E.; Minda, H.; Burus, I.; Molnar, S.; Molnár, D.

In: Lipids, Vol. 35, No. 11, 2000, p. 1179-1184.

Research output: Contribution to journalArticle

Decsi, T. ; Csabi, G. ; Torok, K. ; Erhardt, E. ; Minda, H. ; Burus, I. ; Molnar, S. ; Molnár, D. / Polyunsaturated fatty acids in plasma lipids of obese children with and without metabolic cardiovascular syndrome. In: Lipids. 2000 ; Vol. 35, No. 11. pp. 1179-1184.
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T1 - Polyunsaturated fatty acids in plasma lipids of obese children with and without metabolic cardiovascular syndrome

AU - Decsi, T.

AU - Csabi, G.

AU - Torok, K.

AU - Erhardt, E.

AU - Minda, H.

AU - Burus, I.

AU - Molnar, S.

AU - Molnár, D.

PY - 2000

Y1 - 2000

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AB - Previously we reported significantly higher values of γ-linolenic acid (GLA, 18:3n-6), dihomo-γ-linolenic acid (DHGLA, 20:3n-6), and arachidonic acid (20:4n-6) in plasma lipid classes in obese children than in nonobese controls. In the present study, fatty acid composition of plasma phospholipids (PL) and sterol esters (STE) was determined by high-resolution capillary gas-liquid chromatography in obese children with and without metabolic cardiovascular syndrome [MCS: defined as simultaneous presence of (i) dyslipidemia, (ii) hyperinsulinemia, (iii) hypertension, and (iv) impaired glucose tolerance] and in nonobese controls. Fatty acid composition of PL and STE lipids did not differ between obese children without MCS and controis. Obese children with MCS exhibited significantly lower linoleic acid (LA, 18:2n-6) values in PL (17.43 [2.36], % wt/wt, median [range from the first to the third quartile]) than obese children without MCS (19.14 [3.49]) and controls (20.28 [3.80]). In contrast, PL GLA values were significantly higher in obese children with (0.13 [0.08]) than in those without MCS (0.08 [0.04]), whereas STE GLA values were higher in obese children with MCS (1.04 [0.72]) than in controls (0.62 [0.481). DHGLA values in PL were significantly higher in obese children with MCS (4.06 [0.741) than in controls (2.69 [1.60]). The GLA/LA ratio was significantly higher, whereas the AA/DHGLA ratio was significantly lower in obese children with MCS than in obese children without MCS and in controls. In this study, LA metabolism was affected only in obese children with but not in those without MCS. In obese children with MCS, Δ6-desaturase activity appeared to be stimulated, whereas Δ5-desaturase activity appeared to be inhibited. Disturbances in LA metabolism may represent an additional health hazard within the multifaceted clinical picture of MCS.

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