Polysplenia and situs inversus in siblings: Case reports

Izabella Cesko, Júlia Hajdú, Tamás Marton, László Tarnai, Zoltán Papp

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Heterotaxy syndromes, otherwise laterality defects, are variations from anatomic left-right asymmetry. Situs in-versus is the complete reversal of the normal situs, still situs ambiguus is the randomisation of the normal organ position. Situs ambiguus may be manifested as asplenia or polysplenia syndrome. Normal situs and both types of the heterotaxy syndromes may appear among some affected families, whereas the different situs are rarely expressed in the same family. We describe an autosomal-recessive inherited familial heterotaxy syndrome with two affected siblings - one of whom has situs inversus, and the other with polysplenia syndrome. The polysplenia syndrome was diagnosed by fetal echocardiography. Since the chromosomal or molecular diagnosis of laterality defects are accessible only in X-linked heterotaxy syndromes, the fetal echocardiography is the earliest available diagnostic method in this field. Therefore, fetal echocardiography has great importance for affected families.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalFetal Diagnosis and Therapy
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 8 2001

Keywords

  • Aplenia/polysplenia syndromes
  • Autosomal recessive
  • Fetal echocardiography
  • Heterotaxy syndromes
  • Ivemark syndrome
  • Laterality defects
  • Situs ambiguus
  • Situs inversus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology

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