Polypeptides and immunoreactivity of empty adenovirus type 1 particles.

G. Berencsi, A. Lengyel, N. S. Dyachenko, I. Nász

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two distinct CsCl-stable empty particle populations were characterized in human adenovirus type 1 infected cells. Different sensitivity to proteases and polypeptide composition indicate that empty capsids A and B are degradation products of two different assembly intermediates. Both empty particle populations react with antihexon antibodies similarly to complete virions. Thus the arrangement of exposed type-specific epitopes is suggested to be unchanged during virus assembly. Experimental evidence is presented that both antifibre and antihexon antibodies trigger structural changes of complete virions, which are initiating the specific loss of core protein V from antibody-aggregated virions.

Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalActa Microbiologica Hungarica
Volume30
Issue number3-4
Publication statusPublished - 1983

Fingerprint

Adenoviridae
Virion
Peptides
Antibodies
Viral Core Proteins
Virus Assembly
Human Adenoviruses
Capsid
Population
Epitopes
Peptide Hydrolases

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Polypeptides and immunoreactivity of empty adenovirus type 1 particles. / Berencsi, G.; Lengyel, A.; Dyachenko, N. S.; Nász, I.

In: Acta Microbiologica Hungarica, Vol. 30, No. 3-4, 1983, p. 189-197.

Research output: Contribution to journalArticle

Berencsi, G, Lengyel, A, Dyachenko, NS & Nász, I 1983, 'Polypeptides and immunoreactivity of empty adenovirus type 1 particles.', Acta Microbiologica Hungarica, vol. 30, no. 3-4, pp. 189-197.
Berencsi, G. ; Lengyel, A. ; Dyachenko, N. S. ; Nász, I. / Polypeptides and immunoreactivity of empty adenovirus type 1 particles. In: Acta Microbiologica Hungarica. 1983 ; Vol. 30, No. 3-4. pp. 189-197.
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