Polyols in the development of chewable tablets containing magnesium aspartate

H. Göczõ, P. Szabó-Révész, M. Pásztor-Turák, K. Pintye-Hódi, I. Erös, G. Dombi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Polyols are materials that are successfully used in many fields of the pharmaceutical industry in consequence of their favourable properties. This work reports on preformulation studies (particle size distribution, mass by volume and flow-ability) of different polyols (sorbitol, xylitol and mannitol) used as vehicles to produce chewable tablets containing magnesium aspartate by direct tabletting. The physical parameters (uniformity of mass, friability and crushing strength) and the magnesium content of tablets were determined. The magnesium content was measured by atomic absorption spectrometry. The results allow Pearlitol SD 200® and Neosorb P 20/60® to be suggested as filler and binder materials for the manufacture of chewable tablets.

Original languageEnglish
Pages (from-to)639-643
Number of pages5
JournalPharmazeutische Industrie
Volume63
Issue number6
Publication statusPublished - 2001

Fingerprint

Aspartic Acid
Tablets
Magnesium
Xylitol
Sorbitol
Drug Industry
Mannitol
Particle Size
Spectrum Analysis
polyol

Keywords

  • Atomic absorption spectroscopy
  • Chewable tablets
  • Magnesium aspartate
  • Mannitol
  • Sorbitol
  • Xylitol

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Polyols in the development of chewable tablets containing magnesium aspartate. / Göczõ, H.; Szabó-Révész, P.; Pásztor-Turák, M.; Pintye-Hódi, K.; Erös, I.; Dombi, G.

In: Pharmazeutische Industrie, Vol. 63, No. 6, 2001, p. 639-643.

Research output: Contribution to journalArticle

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