Polymorphonuclear granulocyte chemotaxis and chemotactic factor generation by concanavalin A-stimulated peripheral blood mononuclear cells in patients with psoriasis

M. Csató, A. Dobozy, J. Hunyadi, Sz A. Kenderessy, N. Simon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosanactivated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin A produced an increased amount of lymphocyte derived chemotactic factor (LDCF) as compared to that in the case of healthy persons. The LDCF proved to be chemokinetic for the psoriatic granulocyte. It is postulated that these two phenomena may play a role in the pathogenesis of psoriasis.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalArchives of Dermatological Research
Volume271
Issue number3
DOIs
Publication statusPublished - Oct 1 1981

Keywords

  • Chemotactic factor generation
  • Granulcyte chemotaxis
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

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