Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans

Sophie Lecompte, Fabien Szabo De Edelenyi, Louisa Goumidi, Giuseppe Maiani, George Moschonis, Kurt Widhalm, Dénes Molnár, Anthony Kafatos, Andre Spinneker, Christina Breidenassel, Jean Dallongeville, Aline Meirhaeghe, Patrick Borel

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Abstract

Background: Blood vitamin E concentrations are modulated by dietary, metabolic, and genetic factors. CD36 (cluster of differentiation 36), a class B scavenger receptor, might be involved in tissue vitamin E uptake and thus would influence blood vitamin E concentrations. Objective: The goal of the study was to assess the association between CD36 single nucleotide polymorphisms (SNPs) and plasma α-tocopherol concentrations in humans. Design: A subsample from the adult SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort (n = 621) and the adolescent cross-sectional HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study (n = 993) were genotyped for CD36 SNPs (4 and 10 SNPs, respectively). Fasting plasma α-tocopherol concentrations were assayed by using HPLC. Associations were determined by haplotype analyses and by general linear regression models. Results: In the SU.VI.MAX subsample, haplotype analyses showed that some haplotypes of SNPs rs1984112, rs1527479, rs7755, and rs1527483 tended to be associated with plasma α-tocopherol concentrations (P = 0.08 and P = 0.09 for haplotypes 1222 and 1122, respectively). We then investigated the whole known common genetic variability (10 SNPs) of CD36 in the HELENA Study. Three SNPs were associated with lower plasma α-tocopherol concentrations (rs1984112: 23.2%, P = 0.053; rs1761667: 22.9%, P = 0.046; rs1527479: 23.7%, P = 0.0061). After correction for multiple testing, the association between rs1527479 and α-tocopherol concentrations remained significant. This association was modulated by concentrations of fasting serum triglycerides (P for interaction = 0.006) and long-chain polyunsaturated fatty acids (P for interaction = 0.005). Conclusion: Our results suggest that CD36 can modulate blood α-tocopherol concentrations and may therefore be involved in the intestinal absorption or tissue uptake of vitamin E.

Original languageEnglish
Pages (from-to)644-651
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume93
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lecompte, S., De Edelenyi, F. S., Goumidi, L., Maiani, G., Moschonis, G., Widhalm, K., Molnár, D., Kafatos, A., Spinneker, A., Breidenassel, C., Dallongeville, J., Meirhaeghe, A., & Borel, P. (2011). Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans. American Journal of Clinical Nutrition, 93(3), 644-651. https://doi.org/10.3945/ajcn.110.004176