Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: A preliminary study

Viktória Kovacs, Balazs Gasz, Borbala Balatonyi, Luca Jaromi, Peter Kisfali, Balazs Borsiczky, Gabor Jancso, Nandor Marczin, Sandor Szabados, Bela Melegh, Alotti Nasri, Elisabeth Roth

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were selected to genotype analysis according to exclusion criteria. Patients were divided into the following groups: Group I: control patients (n = 78) without and Group II.: study patients (n = 54) with evidence of perioperative myocardial infarction. Genotyping for GSTP1 A (Ile105Ile/ Ala113Ala), B (Ile105Val/Ala113Ala) and C (Ile105Val/Ala113Val) alleles was performed by using real-time-PCR. The heterozygous AC allele was nearly three times elevated (18.5 vs. 7.7 %) in the patients who suffered postoperative myocardial infarction compared to controls. Contrary, we found allele frequency of 14.1 % for homozygous BB allele in the control group whereas no such allele combination was present in the study group. These preliminary results may suggest the protective role for the B and C alleles during myocardial oxidative stress whereas the A allele may represent predisposing risk for cellular injury in patients undergoing cardiac surgery.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume389
Issue number1-2
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Cardiac surgery
  • Gene polymorphism
  • Glutathione S-transferase P1
  • Perioperative acute myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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