Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer

Mariana C. Stern, Jie Lin, Jonine D. Figueroa, Karl T. Kelsey, Anne E. Kiltie, Jian Min Yuan, Giuseppe Matullo, Tony Fletcher, Simone Benhamou, Jack A. Taylor, Donatella Placidi, Zuo Feng Zhang, Gunnar Steineck, Nathaniel Rothman, Manolis Kogevinas, Debra Silverman, Nuria Malats, Stephen Chanock, Xifeng Wu, Margaret R. KaragasAngeline S. Andrew, Heather H. Nelson, D. Timothy Bishop, Chung Sak Sei, Ananya Choudhury, Jennifer H. Barrett, Faye Elliot, Román Corral, Amit D. Joshi, Manuela Gago-Dominguez, Victoria K. Cortessis, Yong Bing Xiang, Yu Tang Gao, Paolo Vineis, Carlotta Sacerdote, Simonetta Guarrera, Silvia Polidoro, Alessandra Allione, Eugen Gurzau, Kvetoslava Koppova, Rajiv Kumar, P. Rudnai, Stefano Porru, Angela Carta, Marcello Campagna, Cecilia Arici, Sung Shim Lani Park, Montserrat Garcia-Closas

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis.

Original languageEnglish
Pages (from-to)6857-6864
Number of pages8
JournalCancer Research
Volume69
Issue number17
DOIs
Publication statusPublished - Sep 1 2009

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Urinary Bladder Neoplasms
DNA Repair
Smoking
Alleles
Odds Ratio
Confidence Intervals
Meta-Analysis
Genes
Carcinogens
DNA Damage
Single Nucleotide Polymorphism
Reactive Oxygen Species
Carcinogenesis
Urinary Bladder

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Stern, M. C., Lin, J., Figueroa, J. D., Kelsey, K. T., Kiltie, A. E., Yuan, J. M., ... Garcia-Closas, M. (2009). Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer. Cancer Research, 69(17), 6857-6864. https://doi.org/10.1158/0008-5472.CAN-09-1091

Polymorphisms in DNA repair genes, smoking, and bladder cancer risk : Findings from the International Consortium of Bladder Cancer. / Stern, Mariana C.; Lin, Jie; Figueroa, Jonine D.; Kelsey, Karl T.; Kiltie, Anne E.; Yuan, Jian Min; Matullo, Giuseppe; Fletcher, Tony; Benhamou, Simone; Taylor, Jack A.; Placidi, Donatella; Zhang, Zuo Feng; Steineck, Gunnar; Rothman, Nathaniel; Kogevinas, Manolis; Silverman, Debra; Malats, Nuria; Chanock, Stephen; Wu, Xifeng; Karagas, Margaret R.; Andrew, Angeline S.; Nelson, Heather H.; Bishop, D. Timothy; Sei, Chung Sak; Choudhury, Ananya; Barrett, Jennifer H.; Elliot, Faye; Corral, Román; Joshi, Amit D.; Gago-Dominguez, Manuela; Cortessis, Victoria K.; Xiang, Yong Bing; Gao, Yu Tang; Vineis, Paolo; Sacerdote, Carlotta; Guarrera, Simonetta; Polidoro, Silvia; Allione, Alessandra; Gurzau, Eugen; Koppova, Kvetoslava; Kumar, Rajiv; Rudnai, P.; Porru, Stefano; Carta, Angela; Campagna, Marcello; Arici, Cecilia; Park, Sung Shim Lani; Garcia-Closas, Montserrat.

In: Cancer Research, Vol. 69, No. 17, 01.09.2009, p. 6857-6864.

Research output: Contribution to journalArticle

Stern, MC, Lin, J, Figueroa, JD, Kelsey, KT, Kiltie, AE, Yuan, JM, Matullo, G, Fletcher, T, Benhamou, S, Taylor, JA, Placidi, D, Zhang, ZF, Steineck, G, Rothman, N, Kogevinas, M, Silverman, D, Malats, N, Chanock, S, Wu, X, Karagas, MR, Andrew, AS, Nelson, HH, Bishop, DT, Sei, CS, Choudhury, A, Barrett, JH, Elliot, F, Corral, R, Joshi, AD, Gago-Dominguez, M, Cortessis, VK, Xiang, YB, Gao, YT, Vineis, P, Sacerdote, C, Guarrera, S, Polidoro, S, Allione, A, Gurzau, E, Koppova, K, Kumar, R, Rudnai, P, Porru, S, Carta, A, Campagna, M, Arici, C, Park, SSL & Garcia-Closas, M 2009, 'Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer', Cancer Research, vol. 69, no. 17, pp. 6857-6864. https://doi.org/10.1158/0008-5472.CAN-09-1091
Stern, Mariana C. ; Lin, Jie ; Figueroa, Jonine D. ; Kelsey, Karl T. ; Kiltie, Anne E. ; Yuan, Jian Min ; Matullo, Giuseppe ; Fletcher, Tony ; Benhamou, Simone ; Taylor, Jack A. ; Placidi, Donatella ; Zhang, Zuo Feng ; Steineck, Gunnar ; Rothman, Nathaniel ; Kogevinas, Manolis ; Silverman, Debra ; Malats, Nuria ; Chanock, Stephen ; Wu, Xifeng ; Karagas, Margaret R. ; Andrew, Angeline S. ; Nelson, Heather H. ; Bishop, D. Timothy ; Sei, Chung Sak ; Choudhury, Ananya ; Barrett, Jennifer H. ; Elliot, Faye ; Corral, Román ; Joshi, Amit D. ; Gago-Dominguez, Manuela ; Cortessis, Victoria K. ; Xiang, Yong Bing ; Gao, Yu Tang ; Vineis, Paolo ; Sacerdote, Carlotta ; Guarrera, Simonetta ; Polidoro, Silvia ; Allione, Alessandra ; Gurzau, Eugen ; Koppova, Kvetoslava ; Kumar, Rajiv ; Rudnai, P. ; Porru, Stefano ; Carta, Angela ; Campagna, Marcello ; Arici, Cecilia ; Park, Sung Shim Lani ; Garcia-Closas, Montserrat. / Polymorphisms in DNA repair genes, smoking, and bladder cancer risk : Findings from the International Consortium of Bladder Cancer. In: Cancer Research. 2009 ; Vol. 69, No. 17. pp. 6857-6864.
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AU - Yuan, Jian Min

AU - Matullo, Giuseppe

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AU - Taylor, Jack A.

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AU - Zhang, Zuo Feng

AU - Steineck, Gunnar

AU - Rothman, Nathaniel

AU - Kogevinas, Manolis

AU - Silverman, Debra

AU - Malats, Nuria

AU - Chanock, Stephen

AU - Wu, Xifeng

AU - Karagas, Margaret R.

AU - Andrew, Angeline S.

AU - Nelson, Heather H.

AU - Bishop, D. Timothy

AU - Sei, Chung Sak

AU - Choudhury, Ananya

AU - Barrett, Jennifer H.

AU - Elliot, Faye

AU - Corral, Román

AU - Joshi, Amit D.

AU - Gago-Dominguez, Manuela

AU - Cortessis, Victoria K.

AU - Xiang, Yong Bing

AU - Gao, Yu Tang

AU - Vineis, Paolo

AU - Sacerdote, Carlotta

AU - Guarrera, Simonetta

AU - Polidoro, Silvia

AU - Allione, Alessandra

AU - Gurzau, Eugen

AU - Koppova, Kvetoslava

AU - Kumar, Rajiv

AU - Rudnai, P.

AU - Porru, Stefano

AU - Carta, Angela

AU - Campagna, Marcello

AU - Arici, Cecilia

AU - Park, Sung Shim Lani

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