Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies

Judith Demeter, Gerald Messer, Stephanie Rämisch, John B. Mee, Francesco S. Di Giovine, Mathias Schmid, Friedhelm Herrmann, Franz Porzsolt

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Abstract

Alleles of the IL-1 genes are associated with several autoimmune and inflammatory diseases, where they tend to have a role in the severity of the disease rather than in susceptibilty to the disease itself.1 Allele 2 of the variable number tandem repeat (VNTR) polymorphism in the IL-1 receptor antagonist (IL-lra) gene was the first marker of the IL-1 cluster to be associated in this way with severity of chronic, systemic and local inflammatory diseases. Because of the role that IL-1 also plays in the pathobiology of certain hematopoietic disorders, we aimed at examining the allelic distribution of the IL-lra VNTR in leukemias, lymphomas and related malignancies. While in patients with chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL), multiple myeloma (MM) and related disorders, primary acute myeloid leukemia (AMI), chronic myeloid leukemia (CML), and Hodgkin's disease (HD), the allelic distribution of IL-1RN was comparable to that seen in healthy control subjects, in a small group of patients with secondary AMI the frequency of the IL-1RN4 allele appeared to be significantly increased. Key words: Acute myeloid leukemia; chronic lymphocytic leukemia; hairy cell leukemia; tumour necrosis factor; lymphotoxin; polymorphism; genetic association

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalCytokines and Molecular Therapy
Volume2
Issue number2
Publication statusPublished - Dec 1 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology

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    Demeter, J., Messer, G., Rämisch, S., Mee, J. B., Di Giovine, F. S., Schmid, M., Herrmann, F., & Porzsolt, F. (1996). Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies. Cytokines and Molecular Therapy, 2(2), 239-242.