Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies

J. Demeter, G. Messer, S. Ramisch, J. B. Mee, F. S. Di Giovine, M. Schmid, F. Herrmann, F. Porzsolt

Research output: Contribution to journalArticle

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Abstract

Alleles of the IL-1 genes are associated with several autoimmune and inflammatory diseases, where they tend to have a role in the severity of the disease rather than in susceptibilty to the disease itself. Allele 2 of the variable number tandem repeat (VNTR) polymorphism in the IL-1 receptor antagonist (IL-1ra) gene was the first marker of the IL-1 cluster to be associated in this way with severity of chronic, systemic and local inflammatory diseases. Because of the role that IL-1 also plays in the pathobiology of certain hematopoietic disorders, we aimed at examining the allelic distribution of the IL-1ra VNTR in leukemias, lymphomas and related malignancies. While in patients with chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL), multiple myeloma (MM) and related disorders, primary acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and Hodgkin's disease (HD), the allelic distribution of IL-1RN was comparable to that seen in healthy control subjects, in a small group of patients with secondary AML the frequency of the IL-1RN*4 allele appeared to be significantly increased.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalCytokines and Molecular Therapy
Volume2
Issue number4
Publication statusPublished - 1996

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Interleukin-1 Receptors
Hematologic Neoplasms
Interleukin-1
Introns
Minisatellite Repeats
Alleles
Acute Myeloid Leukemia
Genes
Hairy Cell Leukemia
B-Cell Chronic Lymphocytic Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Multiple Myeloma
Hodgkin Disease
Interleukin-4
Autoimmune Diseases
Lymphoma
Healthy Volunteers
Leukemia
Neoplasms

Keywords

  • Acute myeloid leukemia
  • Chronic lymphocytic leukemia
  • Genetic association
  • Hairy cell leukemia
  • Lymphotoxin
  • Polymorphism
  • Tumour necrosis factor

ASJC Scopus subject areas

  • Pharmacology
  • Immunology and Allergy

Cite this

Demeter, J., Messer, G., Ramisch, S., Mee, J. B., Di Giovine, F. S., Schmid, M., ... Porzsolt, F. (1996). Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies. Cytokines and Molecular Therapy, 2(4), 239-242.

Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies. / Demeter, J.; Messer, G.; Ramisch, S.; Mee, J. B.; Di Giovine, F. S.; Schmid, M.; Herrmann, F.; Porzsolt, F.

In: Cytokines and Molecular Therapy, Vol. 2, No. 4, 1996, p. 239-242.

Research output: Contribution to journalArticle

Demeter, J, Messer, G, Ramisch, S, Mee, JB, Di Giovine, FS, Schmid, M, Herrmann, F & Porzsolt, F 1996, 'Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies', Cytokines and Molecular Therapy, vol. 2, no. 4, pp. 239-242.
Demeter, J. ; Messer, G. ; Ramisch, S. ; Mee, J. B. ; Di Giovine, F. S. ; Schmid, M. ; Herrmann, F. ; Porzsolt, F. / Polymorphism within the second intron of the IL-1 receptor antagonist gene in patients with hematopoietic malignancies. In: Cytokines and Molecular Therapy. 1996 ; Vol. 2, No. 4. pp. 239-242.
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