Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease

Csaba Szalai, Márton Keszei, Jenõ Duba, Zoltán Prohászka, Gergely Tibor Kozma, Albert Császár, Sándor Balogh, Zsuzsa Almássy, George Fust, Antal Czinner

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116 Citations (Scopus)

Abstract

Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of this polymorphism in 308 Hungarian patients with CAD referred to coronary bypass surgery, and in 310 controls recruited from the same area. The prevalence of the apoA5-1131C allele was significantly higher among CAD patients than among controls (10.9% versus 5.7%; P<0.001, Odds ratio (OR) = 1.99 (1.30-3.04)). Controls carrying the rare C allele had in average 23.0% (P<0.001), subjects with CAD 13.8% (P<0.001) higher TG levels compared to common allele homozygotes. The polymorphism was not associated with other conventional CAD risk factors or laboratory data of the patients. In logistic regression models adjusted for age, gender, presence of diabetes, BMI, smoking, LDL-C, HDL-C and hypertension a significantly increased risk of developing CAD was found in patients carrying the apoA5-1131C allele (P<0.001; OR=1.98 (1.14-3.48)), suggesting that this allele variant is an independent genetic risk factor for CAD.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalAtherosclerosis
Volume173
Issue number1
DOIs
Publication statusPublished - Mar 2004

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Keywords

  • Atherosclerosis
  • Coronary bypass
  • Polymorphism
  • Triglyceride
  • apoAV

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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