Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease

Csaba Szalai, Márton Keszei, Jenõ Duba, Zoltán Prohászka, Gergely Tibor Kozma, Albert Császár, Sándor Balogh, Zsuzsa Almássy, George Fust, Antal Czinner

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of this polymorphism in 308 Hungarian patients with CAD referred to coronary bypass surgery, and in 310 controls recruited from the same area. The prevalence of the apoA5-1131C allele was significantly higher among CAD patients than among controls (10.9% versus 5.7%; P

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalAtherosclerosis
Volume173
Issue number1
DOIs
Publication statusPublished - Mar 2004

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Genetic Promoter Regions
Coronary Artery Disease
Triglycerides
Genes
Gene Order
Alleles
Apolipoprotein A-V

Keywords

  • apoAV
  • Atherosclerosis
  • Coronary bypass
  • Polymorphism
  • Triglyceride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of this polymorphism in 308 Hungarian patients with CAD referred to coronary bypass surgery, and in 310 controls recruited from the same area. The prevalence of the apoA5-1131C allele was significantly higher among CAD patients than among controls (10.9{\%} versus 5.7{\%}; P",
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T1 - Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease

AU - Szalai, Csaba

AU - Keszei, Márton

AU - Duba, Jenõ

AU - Prohászka, Zoltán

AU - Kozma, Gergely Tibor

AU - Császár, Albert

AU - Balogh, Sándor

AU - Almássy, Zsuzsa

AU - Fust, George

AU - Czinner, Antal

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KW - Triglyceride

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