Poly(methylene blue) modified electrode sensor for haemoglobin

Christopher M A Brett, G. Inzelt, Vilmos Kertesz

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Poly(methylene blue) modified electrodes have been prepared by potential cycling from aqueous electrolyte solution containing methylene blue on glassy carbon substrates. They have been used successfully for the determination of haemoglobin via its electrooxidation at fixed potential using the batch injection analysis technique in which whole blood samples diluted with phosphate or acetate buffer are injected directly over the modified electrode immersed in inert electrolyte. Electrode response is fast, stable, and reproducible. For blood from healthy donors, a good linear correlation was found between the results from the electrochemical injection method and the conventional clinical spectrophotometric measurement after cyanidation. The blood from potentially ill donors showed deviations from the linear correlation suggesting that this may be a good method for detecting haematological problems. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalAnalytica Chimica Acta
Volume385
Issue number1-3
DOIs
Publication statusPublished - Apr 5 1999

Fingerprint

Methylene Blue
hemoglobin
Electrodes
electrode
Hemoglobins
Blood
blood
sensor
electrolyte
Electrolytes
Sensors
Injections
Electrooxidation
Glassy carbon
Blood Donors
acetate
Buffers
Acetates
Carbon
Phosphates

Keywords

  • Batch injection analysis
  • Electrochemical sensor
  • Haemoglobin
  • Modified electrodes
  • Poly(methylene blue)

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Poly(methylene blue) modified electrode sensor for haemoglobin. / Brett, Christopher M A; Inzelt, G.; Kertesz, Vilmos.

In: Analytica Chimica Acta, Vol. 385, No. 1-3, 05.04.1999, p. 119-123.

Research output: Contribution to journalArticle

Brett, Christopher M A ; Inzelt, G. ; Kertesz, Vilmos. / Poly(methylene blue) modified electrode sensor for haemoglobin. In: Analytica Chimica Acta. 1999 ; Vol. 385, No. 1-3. pp. 119-123.
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