Polymethyl-methacrylate-sorbitol-based capsules as local drug delivery vehicles: a preliminary study.

Dorottya Frank, Gellért Cseh, T. Nagy, László Pótó, Béla Kocsis, A. Miseta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Local delivery of antibiotics via PMMA (polymethyl-methacrylate) has been widely used in the treatment of chronic osteomyelitis for over 40 years. Unfortunately, PMMA is water insoluble, which seriously limits antibiotic delivery. In addition, the polymerization temperature of PMMA is high, and consequently, only heat-stable antibiotics can be used. Therefore our aim has been to develop an effective antibiotic delivery system, which can be loaded with a wide variety of drugs and deliver the molecules in a predictable manner. Capsules with wall thicknesses of 0.3-0.6 mm from PMMA mixtures containing 40-70 w/w% (weight percent) of sorbitol were prepared and their permeability tested with BPB (Bromophenol Blue). Sorbitol content and wall thickness correlated with the BPB release. SEM (scanning electron microscopy) showed that the canalization of capsules also was well correlated with both sorbitol content and wall thickness. The PMMA-sorbitol-based capsule can potentially be a versatile tool in assuring effective delivery of antibiotics and other substances.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalCell Biology International
Volume35
Issue number5
DOIs
Publication statusPublished - May 1 2011

Fingerprint

Sorbitol
Polymethyl Methacrylate
Capsules
Anti-Bacterial Agents
Bromphenol Blue
Pharmaceutical Preparations
Osteomyelitis
Polymerization
Electron Scanning Microscopy
Permeability
Hot Temperature
Weights and Measures
Temperature
Water

ASJC Scopus subject areas

  • Cell Biology

Cite this

Polymethyl-methacrylate-sorbitol-based capsules as local drug delivery vehicles : a preliminary study. / Frank, Dorottya; Cseh, Gellért; Nagy, T.; Pótó, László; Kocsis, Béla; Miseta, A.

In: Cell Biology International, Vol. 35, No. 5, 01.05.2011, p. 499-504.

Research output: Contribution to journalArticle

Frank, Dorottya ; Cseh, Gellért ; Nagy, T. ; Pótó, László ; Kocsis, Béla ; Miseta, A. / Polymethyl-methacrylate-sorbitol-based capsules as local drug delivery vehicles : a preliminary study. In: Cell Biology International. 2011 ; Vol. 35, No. 5. pp. 499-504.
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