Polymers and formulation strategies of nanofibrous systems for drug delivery application and tissue engineering

I. Sebe, B. Kállai-Szabó, R. Zelkó, D. Szabó

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

During the last decade, the formulation of nanofibrous materials loaded with different drugs for biomedical applications has evoked considerable interest. The large specific surface area, the special micro- and macrostructure of fiber mats, the possibility for gradual release and site-specific local delivery of the active compounds lead to cytotoxicity decrease and enhancement of the therapeutic effect of drugs and implants. The present review details the different spinning techniques applied for the design of micro- and nanofibrous drug delivery systems. It furthermore deals with the use of various polymers that are capable for the formation of fiber scaffolds of various biomedical applications

Original languageEnglish
Pages (from-to)604-617
Number of pages14
JournalCurrent Medicinal Chemistry
Volume22
Issue number5
Publication statusPublished - 2015

Fingerprint

Drug Implants
Therapeutic Uses
Drug Delivery Systems
Tissue Engineering
Drug delivery
Tissue engineering
Polymers
Lead compounds
Fibers
Cytotoxicity
Scaffolds
Specific surface area
Pharmaceutical Preparations
Microstructure

Keywords

  • Drug delivery
  • Nano- and microfibers
  • Polymers
  • Regenerative medicine
  • Spinning techniques
  • Tissue engineering

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Medicine(all)

Cite this

Polymers and formulation strategies of nanofibrous systems for drug delivery application and tissue engineering. / Sebe, I.; Kállai-Szabó, B.; Zelkó, R.; Szabó, D.

In: Current Medicinal Chemistry, Vol. 22, No. 5, 2015, p. 604-617.

Research output: Contribution to journalArticle

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