Polymer structure and antimicrobial activity of polyvinylpyrrolidone-based iodine nanofibers prepared with high-speed rotary spinning technique

István Sebe, Barnabás Szabó, Zsombor K. Nagy, D. Szabó, László Zsidai, B. Kocsis, R. Zelkó

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Poly(vinylpyrrolidone)/poly(vinylpyrrolidone-vinylacetate)/iodine nanofibers of different polymer ratios were successfully prepared by a high-speed rotary spinning technique. The obtained fiber mats were subjected to detailed morphological analysis using an optical and scanning electron microscope (SEM), while the supramolecular structure of the samples was analyzed by positron annihilation lifetime spectroscopy (PALS). The maximum dissolved iodine of the fiber samples was determined, and microbiological assay was carried out to test their effect on the bacterial growth. SEM images showed that the polymer fibers were linear, homogenous, and contained no beads. The PALS results, both the o-positronium (o-Ps) lifetime values and distributions, revealed the changes of the free volume holes of fibers as a function of their composition and the presence of iodine. The micro- and macrostructural characterisation of polymer fiber mats enabled the selection of the required composition from the point of their applicability as a wound dressing.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume458
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Nanofibers
Povidone-Iodine
Polymers
Iodine
Electrons
Spectrum Analysis
Bandages
Wounds and Injuries
Growth

Keywords

  • Antimicrobial activity
  • Fiber composite
  • High-speed rotary spinning
  • Positron annihilation lifetime spectroscopy (PALS)
  • PVP-iodine

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Polymer structure and antimicrobial activity of polyvinylpyrrolidone-based iodine nanofibers prepared with high-speed rotary spinning technique. / Sebe, István; Szabó, Barnabás; Nagy, Zsombor K.; Szabó, D.; Zsidai, László; Kocsis, B.; Zelkó, R.

In: International Journal of Pharmaceutics, Vol. 458, No. 1, 2013, p. 99-103.

Research output: Contribution to journalArticle

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AU - Zsidai, László

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