Polyhydroxy cyclohexanols from a dendrodochium sp. fungus associated with the sea cucumber holothuria nobilis selenka

Dong Xiao Xu, Peng Sun, Tibor Kurtán, Attila Mándi, Hua Tang, Baoshu Liu, William H. Gerwick, Zhi Wei Wang, Wen Zhang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Four cyclohexanol analogues, dendrodochols A-D (1-4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis. The absolute configurations were assigned using a solution TDDFT/ECD calculation approach and the modified Mosher's method. In an in vitro bioassay, these compounds exhibited no growth inhibition activity against the A549 and MG63 cell lines. Dendrodochols 1 and 3 exhibited modest antifungal activity against Candida strains, Cryptococcus neoformans, and Trichophyton rubrum, whereas 2 and 4 showed no activity against the tested strains.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalJournal of Natural Products
Volume77
Issue number5
DOIs
Publication statusPublished - May 23 2014

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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