Poly(amino acid)s

Promising enzymatically degradable stealth coatings for liposomes

Birgit Romberg, Josbert M. Metselaar, Lajos Baranyi, Cor J. Snel, Rolf Bünger, Wim E. Hennink, J. Szebeni, Gert Storm

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Poly(amino acid)s (PAAs) were evaluated as coating polymers for long-circulating liposomes. The pharmacokinetics of PAA-coated liposomes were assessed in rats. Prolonged circulation times were obtained, comparable to those reported for poly(ethylene glycol) (PEG)-liposomes. Besides, the enzymatic degradability of PAAs was studied. PAAs - in free as well as liposome-associated form - are degradable by proteases, which is beneficial for reducing the risks of accumulation in vivo. Furthermore, complement activation by PAA-liposomes was evaluated in vitro and in vivo. Like other liposome types, they appear to activate the complement system. However, a role of endotoxin contamination of the PAA-liposome formulations used cannot be excluded in our complement activation studies.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume331
Issue number2
DOIs
Publication statusPublished - Mar 1 2007

Fingerprint

Liposomes
Amino Acids
Complement Activation
Ethylene Glycol
Endotoxins
Polymers
Peptide Hydrolases
Pharmacokinetics

Keywords

  • Complement activation
  • Enzymatic degradability
  • Long-circulating liposomes
  • Pharmacokinetics
  • Poly(amino acid)-coatings

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Romberg, B., Metselaar, J. M., Baranyi, L., Snel, C. J., Bünger, R., Hennink, W. E., ... Storm, G. (2007). Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes. International Journal of Pharmaceutics, 331(2), 186-189. https://doi.org/10.1016/j.ijpharm.2006.11.018

Poly(amino acid)s : Promising enzymatically degradable stealth coatings for liposomes. / Romberg, Birgit; Metselaar, Josbert M.; Baranyi, Lajos; Snel, Cor J.; Bünger, Rolf; Hennink, Wim E.; Szebeni, J.; Storm, Gert.

In: International Journal of Pharmaceutics, Vol. 331, No. 2, 01.03.2007, p. 186-189.

Research output: Contribution to journalArticle

Romberg, B, Metselaar, JM, Baranyi, L, Snel, CJ, Bünger, R, Hennink, WE, Szebeni, J & Storm, G 2007, 'Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes', International Journal of Pharmaceutics, vol. 331, no. 2, pp. 186-189. https://doi.org/10.1016/j.ijpharm.2006.11.018
Romberg, Birgit ; Metselaar, Josbert M. ; Baranyi, Lajos ; Snel, Cor J. ; Bünger, Rolf ; Hennink, Wim E. ; Szebeni, J. ; Storm, Gert. / Poly(amino acid)s : Promising enzymatically degradable stealth coatings for liposomes. In: International Journal of Pharmaceutics. 2007 ; Vol. 331, No. 2. pp. 186-189.
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