Polyamine metabolism in transient focal ischemia of rat brain

Wulf Paschen, Laszlo Csiba, Gabriele Röhn, Daniel Bereczki

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38 Citations (Scopus)

Abstract

Polyamine metabolism was studied in rat brains subjected to 30 min transient cerebral ischemia by measuring the activity of the key enzyme ornithine decarboxylase (ODC) and levels of the polyamines putrescine, spermidine and spermine. A transient increase in ODC activity was apparent after 4 h of recirculation in the ipsilateral cortex and striatum (P < 0.05). Putrescine levels were significantly increased in the ipsilateral striatum after 4 h of recirculation, and after 24 h of recirculation in both the ipsilateral cortex and striatum. During ischemia spermidine levels were significantly reduced in the ipsilateral hemisphere and spermine levels in the ipsilateral cortex. It is suggested that during ischemia polyamines are released from neurons into the extracellular compartment and cleared into the blood.

Original languageEnglish
Pages (from-to)354-357
Number of pages4
JournalBrain research
Volume566
Issue number1-2
DOIs
Publication statusPublished - Dec 6 1991

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Keywords

  • Brain
  • Focal cerebral ischemia
  • N-Methyl-d-aspartate receptor
  • Ornithine decarboxylase
  • Polyamine
  • Putrescine
  • Rat
  • Spermidine
  • Spermine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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