Poly(ADP-ribose) polymerases in aging – friend or foe?

András Vida, Omar Abdul-Rahman, Edit Mikó, Attila Brunyánszki, P. Bai

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

Original languageEnglish
Pages (from-to)705-712
Number of pages8
JournalCurrent Protein and Peptide Science
Volume17
Issue number7
Publication statusPublished - Nov 1 2016

Fingerprint

DNA Repair Enzymes
Poly(ADP-ribose) Polymerases
Aging of materials
DNA
Metabolic Diseases
Repair
Chemical activation
DNA Repair
DNA Damage
Cellular radio systems
Stem Cells
Communication
Cell Proliferation
Cell proliferation
Enzymes
Stem cells
Food
Nutrients

Keywords

  • Aging
  • DNA repair
  • Energy stress
  • Healthspan
  • Mitochondria
  • PARPs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Vida, A., Abdul-Rahman, O., Mikó, E., Brunyánszki, A., & Bai, P. (2016). Poly(ADP-ribose) polymerases in aging – friend or foe? Current Protein and Peptide Science, 17(7), 705-712.

Poly(ADP-ribose) polymerases in aging – friend or foe? / Vida, András; Abdul-Rahman, Omar; Mikó, Edit; Brunyánszki, Attila; Bai, P.

In: Current Protein and Peptide Science, Vol. 17, No. 7, 01.11.2016, p. 705-712.

Research output: Contribution to journalReview article

Vida, A, Abdul-Rahman, O, Mikó, E, Brunyánszki, A & Bai, P 2016, 'Poly(ADP-ribose) polymerases in aging – friend or foe?', Current Protein and Peptide Science, vol. 17, no. 7, pp. 705-712.
Vida A, Abdul-Rahman O, Mikó E, Brunyánszki A, Bai P. Poly(ADP-ribose) polymerases in aging – friend or foe? Current Protein and Peptide Science. 2016 Nov 1;17(7):705-712.
Vida, András ; Abdul-Rahman, Omar ; Mikó, Edit ; Brunyánszki, Attila ; Bai, P. / Poly(ADP-ribose) polymerases in aging – friend or foe?. In: Current Protein and Peptide Science. 2016 ; Vol. 17, No. 7. pp. 705-712.
@article{7bf44143cfb848cfa0fe4888fa9d5048,
title = "Poly(ADP-ribose) polymerases in aging – friend or foe?",
abstract = "Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.",
keywords = "Aging, DNA repair, Energy stress, Healthspan, Mitochondria, PARPs",
author = "Andr{\'a}s Vida and Omar Abdul-Rahman and Edit Mik{\'o} and Attila Bruny{\'a}nszki and P. Bai",
year = "2016",
month = "11",
day = "1",
language = "English",
volume = "17",
pages = "705--712",
journal = "Current Protein and Peptide Science",
issn = "1389-2037",
publisher = "Bentham Science Publishers B.V.",
number = "7",

}

TY - JOUR

T1 - Poly(ADP-ribose) polymerases in aging – friend or foe?

AU - Vida, András

AU - Abdul-Rahman, Omar

AU - Mikó, Edit

AU - Brunyánszki, Attila

AU - Bai, P.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

AB - Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

KW - Aging

KW - DNA repair

KW - Energy stress

KW - Healthspan

KW - Mitochondria

KW - PARPs

UR - http://www.scopus.com/inward/record.url?scp=84989233687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989233687&partnerID=8YFLogxK

M3 - Review article

C2 - 27090903

AN - SCOPUS:84989233687

VL - 17

SP - 705

EP - 712

JO - Current Protein and Peptide Science

JF - Current Protein and Peptide Science

SN - 1389-2037

IS - 7

ER -