Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

Peter Bai, Lilla Nagy, Tamás Fodor, Lucas Liaudet, Pal Pacher

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondrial damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Keywords

  • AMP activated kinase
  • Hypoxia-inducible factor
  • NAD
  • Nuclear respiratory factor
  • Poly(ADP-ribose) polymerase
  • Sirtuin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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