Poly(ADP-ribose) polymerase-2: Emerging transcriptional roles of a DNA-repair protein

Magdolna Szántó, Attila Brunyánszki, Borbála Kiss, Lilla Nagy, Pál Gergely, László Virág, Péter Bai

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Poly(ADP-ribose) polymerase (PARP)-2 is a nuclear enzyme that belongs to thePARPfamily andPARP-2 is responsible for 5-15 % of total cellular PARP activity. PARP-2 was originally described in connection to DNA repair and in physiological and pathophysiological processes associated with genome maintenance (e.g., centromere and telomere protection, spermiogenesis, thymopoiesis, azoospermia, and tumorigenesis). Recent reports have identified important rearrangements in gene expression upon the knockout of PARP-2. Such rearrangements heavily impact inflammation and metabolism. Metabolic effects are mediated through modifying PPARc and SIRT1 function. Altered gene expression gives rise to a complex phenotype characterized primarily by enhanced mitochondrial activity that results both in beneficial (loss of fat, enhanced insulin sensitivity) and in disadvantageous (pancreatic beta cell hypofunction upon high fat feeding) consequences. Enhanced mitochondrial biogenesis provides protection in oxidative stress-related diseases. Hereby, we review the recent developments in PARP-2 research with special attention to the involvement of PARP-2 in transcriptional and metabolic regulation.

Original languageEnglish
Pages (from-to)4079-4092
Number of pages14
JournalCellular and Molecular Life Sciences
Volume69
Issue number24
DOIs
Publication statusPublished - Dec 1 2012

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Keywords

  • ARTD2
  • DNA repair
  • Differentiation
  • Metabolism
  • Mitochondria
  • PARP-2
  • SIRT1

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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