Poly(ADP-ribose) in the skin and in melanomas

Zsuzsanna Géhl, Péter Bai, Edina Bodnár, Gabriella Emri, Éva Remenyik, János Németh, Pál Gergely, László Virág, Éva Szabó

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8 Citations (Scopus)

Abstract

Cutaneous melanoma (CM) and uveal melanoma (UM) represent the most aggressive pigment cell tumor types. Our investigation examined the signaling molecule poly(ADP-ribose) (PAR) in CM and UM. We have demonstrated PAR in keratinocytes, sebocytes, hair follicles, endothelial cells and in subcutaneous adipocytes in the normal skin indicating that PAR may regulate physiological functions in these cell types. Furthermore, CM cells were PAR positive and tumor invasion level/thickness of CM correlated with the PAR content of the cell nuclei, with higher Clark and Breslow indices and AJCC scores associating with higher PAR content. This correlation was especially marked in the samples of female patients. In UM tumors (n=12) a slight overall and strong perivascular PAR staining was observed with considerable individual variations. In view of recent successful clinical trials with PARP inhibitors as adjuvant chemotherapeutic agents, our results suggest that melanomas may display differential sensitivity towards this novel therapeutic modality which should be considered for the selection of patients.

Original languageEnglish
Pages (from-to)651-659
Number of pages9
JournalHistology and Histopathology
Volume27
Issue number5
Publication statusPublished - May 1 2012

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Keywords

  • Melanoma
  • Poly(ADP-ribose)
  • Poly(ADP-ribose) polymerase
  • Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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