Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: Lessons learned from its inhibitors

Anna Mária Cseh, Zsolt Fábián, Balázs Sümegi, Luca Scorrano

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adeninedinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the DNA repair machinery, recent works revealed a more intricate physiologic role of poly(ADP-ribose) polymerases with numerous extranuclear activities. Indeed, poly(ADP-ribose) polymerases participate in fundamental cellular processes like chromatin remodelling, transcription or regulation of the cell-cycle. These new insight into the physiologic roles of poly(ADP-ribose) polymerases widens the range of human pathologies in which pharmacologic inhibition of these enzymes might have a therapeutic potential. Here, we overview our current knowledge on extranuclear functions of poly(ADP-ribose) polymerases with a particular focus on the mitochondrial ones and discuss potential fields of future clinical applications.

Original languageEnglish
Pages (from-to)50221-50239
Number of pages19
JournalOncotarget
Volume8
Issue number30
DOIs
Publication statusPublished - 2017

Keywords

  • Cancer
  • Mitochondria
  • PARP
  • Signaling
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology

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