Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: Lessons learned from its inhibitors

Anna Mária Cseh, Zsolt Fábián, B. Sümegi, Luca Scorrano

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adeninedinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the DNA repair machinery, recent works revealed a more intricate physiologic role of poly(ADP-ribose) polymerases with numerous extranuclear activities. Indeed, poly(ADP-ribose) polymerases participate in fundamental cellular processes like chromatin remodelling, transcription or regulation of the cell-cycle. These new insight into the physiologic roles of poly(ADP-ribose) polymerases widens the range of human pathologies in which pharmacologic inhibition of these enzymes might have a therapeutic potential. Here, we overview our current knowledge on extranuclear functions of poly(ADP-ribose) polymerases with a particular focus on the mitochondrial ones and discuss potential fields of future clinical applications.

Original languageEnglish
Pages (from-to)50221-50239
Number of pages19
JournalOncotarget
Volume8
Issue number30
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases
Adenosine Diphosphate Ribose
Therapeutics
Chromatin Assembly and Disassembly
Niacinamide
Enzymes
DNA Repair
Cell Cycle
Pathology
DNA
Proteins

Keywords

  • Cancer
  • Mitochondria
  • PARP
  • Signaling
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology

Cite this

Poly(adenosine diphosphate-ribose) polymerase as therapeutic target : Lessons learned from its inhibitors. / Cseh, Anna Mária; Fábián, Zsolt; Sümegi, B.; Scorrano, Luca.

In: Oncotarget, Vol. 8, No. 30, 01.01.2017, p. 50221-50239.

Research output: Contribution to journalReview article

Cseh, Anna Mária ; Fábián, Zsolt ; Sümegi, B. ; Scorrano, Luca. / Poly(adenosine diphosphate-ribose) polymerase as therapeutic target : Lessons learned from its inhibitors. In: Oncotarget. 2017 ; Vol. 8, No. 30. pp. 50221-50239.
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