Poly- γ -glutamic acid nanoparticles based visible light-curable hydrogel for biomedical application

József Bakó, Farkas Kerényi, Edit Hrubi, István Varga, L. Daróczi, Beatrix Dienes, L. Csernoch, József Gáll, Csaba Hegedus

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nanoparticles and hydrogels have gained notable attention as promising potential for fabrication of scaffolds and delivering materials. Visible light-curable systems can allow for the possibility of in situ fabrication and have the advantage of optimal applicability. In this study nanogel was created from methacrylated poly-gamma-glutamic acid nanoparticles by visible (dental blue) light photopolymerization. The average size of the particles was 80 nm by DLS, and the NMR spectra showed that the methacrylation rate was 10%. Polymerization time was 3 minutes, and a stable nanogel with a swelling rate of 110% was formed. The mechanical parameters of the prepared structure (compression stress 0.73 MPa, and Young's modulus 0.93 MPa) can be as strong as necessary in a real situation, for example, in the mouth. A retaining effect of the nanogel was found for ampicillin, and the biocompatibility of this system was tested by Alamar Blue proliferation assay, while the cell morphology was examined by fluorescence and laser scanning confocal microscopy. In conclusion, the nanogel can be used for drug delivery, or it can be suitable for a control factor in different systems.

Original languageEnglish
Article number7350516
JournalJournal of Nanomaterials
Volume2016
DOIs
Publication statusPublished - 2016

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Hydrogel
Hydrogels
Glutamic Acid
Nanoparticles
Fabrication
Acids
Photopolymerization
Confocal microscopy
Drug delivery
Biocompatibility
Scaffolds
Swelling
Assays
Elastic moduli
Fluorescence
Polymerization
Nuclear magnetic resonance
Scanning
Lasers
Ampicillin

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Poly- γ -glutamic acid nanoparticles based visible light-curable hydrogel for biomedical application. / Bakó, József; Kerényi, Farkas; Hrubi, Edit; Varga, István; Daróczi, L.; Dienes, Beatrix; Csernoch, L.; Gáll, József; Hegedus, Csaba.

In: Journal of Nanomaterials, Vol. 2016, 7350516, 2016.

Research output: Contribution to journalArticle

Bakó, József ; Kerényi, Farkas ; Hrubi, Edit ; Varga, István ; Daróczi, L. ; Dienes, Beatrix ; Csernoch, L. ; Gáll, József ; Hegedus, Csaba. / Poly- γ -glutamic acid nanoparticles based visible light-curable hydrogel for biomedical application. In: Journal of Nanomaterials. 2016 ; Vol. 2016.
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AU - Daróczi, L.

AU - Dienes, Beatrix

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