Polarization wave at the onset of collective cell migration

Dietmar Oelz, Hamid Khataee, A. Czirók, Zoltan Neufeld

Research output: Contribution to journalArticle

Abstract

Collective cell migration underlies morphogenesis, tissue regeneration, and cancer progression. How the biomechanical coupling between epithelial cells triggers and coordinates the collective migration is an open question. Here, we develop a one-dimensional model for an epithelial monolayer which predicts that after the onset of migration at an open boundary, cells in the bulk of the epithelium are gradually recruited into outward-directed motility, exhibiting traveling-wave-like behavior. We find an exact formula for the speed of this motility wave proportional to the square root of the cells' contractility, which accounts for cortex tension and adhesion between adjacent cells.

Original languageEnglish
Article number032403
JournalPhysical Review E
Volume100
Issue number3
DOIs
Publication statusPublished - Sep 5 2019

Fingerprint

polarization (waves)
Cell Migration
Polarization
Motility
locomotion
Cell
cells
Migration
Contractility
Morphogenesis
epithelium
cortexes
Regeneration
Cortex
Adhesion
One-dimensional Model
regeneration
Progression
Square root
Trigger

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Polarization wave at the onset of collective cell migration. / Oelz, Dietmar; Khataee, Hamid; Czirók, A.; Neufeld, Zoltan.

In: Physical Review E, Vol. 100, No. 3, 032403, 05.09.2019.

Research output: Contribution to journalArticle

Oelz, Dietmar ; Khataee, Hamid ; Czirók, A. ; Neufeld, Zoltan. / Polarization wave at the onset of collective cell migration. In: Physical Review E. 2019 ; Vol. 100, No. 3.
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