Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma

Zsolt Orosz, Béla Rohonyi, Antal Luksander, János Szántó

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3 Citations (Scopus)


A case of a metachronous epithelioid sarcoma and pleomorphic liposarcoma in a young woman is described. The first tumor was an epithelioid sarcoma (ES) with focal rhabdoid features localised in the left calf while the second lesion developed seven years later in the same region was diagnosed as pleomorphic liposarcoma resembling myxofibrosarcoma ("myxoid variant of malignant fibrous histiocytoma") predominantly composed of moderately, differentiated spindle cells. Multiple foci of uni- and plurivacuolated lipoblasts were seen. Following the resection of ES the patient received 57 Gy radiation to the region, therefore we regarded the second tumor as a radiation induced liposarcoma. A further interesting feature of this case is that the development of pleomorphic liposarcoma preceded by 6 months the solitary right parabronchial metastasis of ES and after 4 months of metastasectomy a third tumor developed at the site of the first lesion. This tumor showed dedifferentiation toward pleomorphic malignant fibrous histiocytoma. Our case represents a unique case of postirradiation liposarcoma developed on the base of ES.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalPathology and Oncology Research
Issue number4
Publication statusPublished - Jan 1 2000


  • Epithelioid sarcoma
  • Pleomorphic liposarcoma
  • Postirradiation sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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